Investigation on the Cutoff Point for Glycosylated Hemoglobin in Dali Region

Abstract

Abstract:

Objective: To investigate the feasibility of hemoglobin A1C（HbA1C）diagnosing type 2 diabetes mellitus and Impaired
Fasting Glucose（IFG）, and determine the diagnostic cut point. Methods: Oral Glucose Tolerance Test（OGTT）and HbA1C were
detected in patients with 332 cases of type 2 diabetes mellitus（T2DM） and 175 cases of Impaired Fasting Glucose. Receiver
Operating Characteristic Curve（ROC）was used to determine the optimal HbA1C diagnostic cutoff point for type 2 diabetes mellitus.
Results: The FBG and HbA1C levels of the IFG and T2DM group were higher than normal healthy control group with statistical
significance（P<0.05）. According to ROC, the optimal cutoff point of HbA1C for the diagnosis of type 2 diabetes mellitus was 6.25%,
and its sensitivity was 86.5%, its specificity 95.2%, the AUC was 0.959（95% CI: 0.945-0.973）. Conclusion: The optimal cutoff point
of HbA1C for the diagnosis of Impaired Fasting Glucose was 5.51%, and the optimal cutoff point of HbA1c for the diagnosis of type 2
diabetes mellitus was 6.25%. HbA1C is an available parameter in diagnosing T2DM.

Key words: diabetes mellitus, HbA1c, Impaired Fasting Glucose

CLC Number:

R587.1

He Yingchun, Zhu Xingcheng, Yin Bo, Wang Dongju. Investigation on the Cutoff Point for Glycosylated Hemoglobin in Dali Region[J]. J4, 2016, 1(4): 64-66.

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