J4 ›› 2016, Vol. 1 ›› Issue (8): 56-59.

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Effect of Propofol on the Treatment of Severe Traumatic Brain Injury with Continuous Invasive
Intracranial Pressure Monitoring

  

  1. (Department of Neurosurgery in The First People's Hospital of Kunming, Kunming 650011, China)
  • Received:2015-03-25 Revised:2015-07-17 Online:2016-08-15 Published:2016-08-15

Abstract:

Objective: To investigate the clinical significance of propofol on the treatment of severe traumatic brain injury with
continuous invasive intracranial pressure monitoring. Methods: 32 patients were randomly divided into 2 groups with invasive
intracranial pressure monitoring. In propofol group, patients were given continuous intravenous pumping of propofol for 1-4 days.
Patients in the control group were given a regular treatment of neurosurgery. Close observation of GCS scoring, ICP change rate, total
amount of mannitol and complication was carried out. Results: Two groups had no significant difference in GCS scoring in 1 week(P >
0.05). On the 3rd day and 4th day, the decrease of ICP of propofol group was greater than that of control group. The total amount of
mannitol of experiment group was obviously smaller than that of control group on the 2nd day, the 3rd day and 4th day(P< 0.05).
Conclusion: In a certain period of time, propofol would help reduce the ICP, thus decreasing the total amount of mannitol. However, it
showed no significance in short-term prognosis.

Key words: invasive intracranial pressure monitoring, propofol, severe traumatic brain injury, intracranial pressure

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