Abstract:

Objective: To investigate the clinical distribution and antibiotic resistance of Streptococcus pneumoniae in the Affiliated
Hospital of Dali University in order to provide reference for clinical diagnosis and treatment. Methods: A total of 98 S. pneumoniae
were obtained from March 2011 to March 2014. The identification and drug sensitive test of all strains were measured by VITEK-2
Compact analyzer. Drug sensitivity results were interpreted by using the American Clinical and Laboratory Standards Institute（CLSI）
2012 Edition. The resistance results were analyzed via WHONET 5.6 software. Results: Among 98 strains of S. pneumoniae, 77 strains
were isolated from sputum, 15 from pharynx swab, 3 from blood and 2 from cerebrospinal fluid. Those strains were mainly from
Paediatrics, Respiratory Medicine, ICU, and Dermatology, respectively 34, 27, 16, and 11. 52 of the strains were from children of 5 and
under, and 34 were from the elderly people of 60 or over. The assay showed that the resistance rates of S. Pneumoniae to erythromycin,
tetracycline and SMZ-TMZ were relatively high, reaching 90.8%, 81.6% and 80.6% respectively. The resistance rateto penicillin was
26.5%. The resistance rates to cefotaxime, ertapenem, amoxicillin, meropenem and ceftriaxone were less than 20%. No vancomycin and
moxifloxacin and linezolidresistant strain was found. Conclusion：S. pneumoniae infection were mainly caused by respiratory infection.
S. pneumoniae infection was the commonest in children and the elderly. We should use antibiotics rationally so as to prevent the
increase of drug-resistant bacteria.

Key words: Streptococcus pneumoniae, clinical distribution, antibiotic resistance