Correlation of Ultrasound Morphologic Features with the Expressions of CerbB-2,Ki67 and
P53 in Breast Carcinoma

Abstract

Abstract:

Objective：To research the correlation of ultrasound features with the expressions of cerbB-2, Ki67 and P53 in breast
carcinoma and evaluate the clinical application value. Methods: 165 cases of breast carcinoma confirmed by pathologic proofs were
retrospectively analyzed. The ultrasound features and results of specimens stained for cerbB-2, Ki67 and P53 with immunohistochemical
method were studied. Results: ①There was a positive correlation between the diameter of breast carcinoma,the blood flow grade, and
the expression of Ki67（P＜0.05）. ② There was a negative correlation between spicular signs, posterior echo attenuation, and the
expression of cerbB-2（P＜0.05）.③The risk factor related to Ki67 expression was the grade of blood. The expression of Ki67 increased
significantlyinbreast carcinoma with the blood flow grade Ⅱ-Ⅲ. GradeⅡ-Ⅲ often showed central and penetrating vascularity patterns,
with the latter dominating. ④There was not a correlation between peripheral acoustic halo, micro-calcification, the axillary lymph nodes
metastasis，vascularity patterns of breast carcinoma, and the expressions of Ki67, P53,cerbB-2. Conclusion: Ultrasound performance of
breast carcinoma has relevance with cerbB-2 and Ki67 expressions.The combined analysis of the above mentioned factors can provide
clinical application valuein diagnosis , treatment and prognosis of breast carcinoma.

Key words: breast carcinoma, ultrasonography, biologic factors cerbB-2, Ki67, P53

CLC Number:

R445.1

CaoYa,Yang Lichun. Correlation of Ultrasound Morphologic Features with the Expressions of CerbB-2,Ki67 and
P53 in Breast Carcinoma[J]. J4, 2016, 1(8): 70-75.

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