Abstract:

Objective: To evaluate clinical efficacy of biological amniotic membrane transplantation and autologous limbal stem cell
transplantation in the treatment of pterygium. Methods: 245 eyes in 240 cases of pterygium hospitalized were randomly divided into treatment group and control group（120 cases in each group）. The treatment group received pterygium resection and biological amniotic membrane transplantation; the control group received pterygium excision combined with autologous limbal stem cell transplantation.There were 122 eyes in the treatment group, 123 eyes in the control group. Postoperative ocular conditions, corneal and conjunctival epithelial healing, patients with symptoms, relapse rates, and changes in vision were observed. Results: After a week of ocular surface assessment, 115 eyes were fine in the treatment group, accounting for 94.3%. 95 fine in the control group（77.2%）. The postoperative corneal and conjunctival epithelial healing time for the treatment group was 3 to 7 days, three-day healing rate was 73.1%. The healing time for the control group was 3 to 10 days and the three-day healing rate was 53.6%. The time of the treatmentment group was significantly shorter than that of the control group; patient's rational symptom a week after was better in the treatment group than the
control group. In the 24-month postoperative follow-up, the recurrence rate was 7% in the treatment group, the control was 13%.Conclusion: The postoperative ocular conditions and the rational symptoms of pterygium resection and biological amniotic membrane transplantation were better than the limbal stem cell transplantation. The overall 24-month follow-up recurrence rate was significantly lower than the control group. Disposed with SPSS12.0 software, D/F was 3, χ2 =98.45, the difference was significant（P<0.01）. Obvious visual acuity improvement was rarely found, few was improved due to the elimination of the cause of pterygium corneal astigmatism, but after SPSS12.0 software processing, the degree of freedom was 2, χ2 =1.66, with no significant difference（P>0.05）.

Key words: biological amnion, limbal stem cells, pterygium, transplantation