Meta-analysis of the Efficacy and Safety of Voriconazole as Anti-fungal Prophylaxis in Invasive Fungal
Infection after Hematopoietic Stem Cell Transplantation（HSCT）

Abstract

Abstract:

Objective: To systematically review the efficacy and safety of voriconazole what was used to prevent the invasive fungal
infection by patients after hematopoietic stem- cell transplantation. Methods: The PubMed, Medline, Cochrane Library, EMbase,
CNKI, CBM, Wangfang, VIP databases were searched to find out the randomized controlled trials about the efficacy and safety of
voriconazole as anti-fungal prophylaxis of invasive fungal infection after hematopoietic stem-cell transplantation. Quality and extracted
information of the clinical trials were evaluated. Meta-analysis was performed using RevMan 5.3 software. Results: 4 RCTs were
included, involving 1 325 patients. Results of Meta-analysis showed: voriconazole could reduce IFI after hematopoietic stem-cell
transplantation［RR=0.57, 95% CI（0.38, 0.86）, P<0.01］and decrease the incidence of ADR［RR=0.78, 95% CI（0.64, 0.95）, P=
0.01］. There was no statistical significance in mortality among voriconazole, fluconzole and itraconzole［RR=0.84, 95% CI（0.58,
1.20）, P=0.33］. Conclusion: Voriconazole as anti- fungal prophylaxis of invasive fungal infection can effectively reduce the
occurrence of IFI and ADR after hematopoietic stem-cell transplantation.

Key words: voriconazole, Hematopoietic stem cell transplantation, invasive fungal infection, Meta-analysis

CLC Number:

R978.5

Mao Panpan, Du Yimin, Zhang Yang, Lu Wei, Li Xingde, Song Cangsang. Meta-analysis of the Efficacy and Safety of Voriconazole as Anti-fungal Prophylaxis in Invasive Fungal
Infection after Hematopoietic Stem Cell Transplantation（HSCT）[J]. , 2017, 2(2): 31-36.

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