Study on the Association between the Polymorphism of miR-27a and miR-605 Genes and Severe#br#
Spermatogenesis Impairment

doi:10. 3969 / j. issn. 2096-2266. 2021. 02. 012

Abstract

Abstract: Objective: To investigate the association between the polymorphism of SNP rs895819 in miR-27a gene as well as SNP
rs2043556 in miR-605 gene and severe spermatogenesis impairment. Methods: The polymorphic distribution of SNP rs895819 and
rs2043556 were investigated by using polymerase chain reaction and restriction fragment length polymorphism assay in 318 patients
with severe spermatogenesis impairment （including azoospermia and severe oligospermia） and 234 normal men. Results: The
frequencies of allele C（36.2% vs. 29.1%, P = 0.013, OR = 1.383, 95%CI is 1.070-1.788）and individuals with allele C（TC/CC）
（57.2% vs. 48.3%, P = 0.037, OR = 1.433, 95%CI is 1.021-2.012）were significantly higher in patients with severe spermatogenesis
impairment than normal men, whereas genotype TT（42.8% vs. 51.7%，P =0.037，OR =0.698，95%CI is 0.497~0.980）was significantly
lower than normal men at SNP rs2043556 locus. The differencesinalleleandgenotypefrequenciesofSNPrs8959189werenotsignificant
betweenpatientsand normal men（P>0.05）.Conclusion: The polymorphism of SNP rs2043556 in miR-605 gene may be associated with
severe spermatogenesis impairment and affect the risk of severe spermatogenesis impairment.

Key words: severe spermatogenesis impairment, polymorphism, miR-27a, miR-605

CLC Number:

R394.1

Sun Wenwen, Ke Hongli, A Zhoucun. Study on the Association between the Polymorphism of miR-27a and miR-605 Genes and Severe#br# Spermatogenesis Impairment[J]. Journal of Dali University, 2021, 6(2): 59-62.

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Study on the Association between the Polymorphism of miR-27a and miR-605 Genes and Severe#br# Spermatogenesis Impairment

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