Study on in vitro Lipid-Lowering Activity of 33 Compositae Plants from West Yunnan

Abstract

Abstract: Objective：To determine the in vitro lipid-lowering activity of 33 Compositae plants from West Yunnan，and to provide
a scientific basis for the discovery of novel hypolipidemic drugs from plants. Methods：33 Compositae plants were extracted by reflux
method with 75% ethanol. A high-lipid model of HepG2 cells was used to determine the lipid-lowering activities of plant extracts in
vitro. And the lipid-lowering rate was used to evaluate the activity. Results：24 Compositae plant extracts exhibited in vitro lipidlowering
activity in different degrees. The Conyza blinii，Ageratina adenophora，Bidens tripartita，Tithonia diversifolia showed
significant in vitro lipid-lowering activities with lipid-lowering rates of（18.4±1.9）%，（18.4±9.7）%，（17.5±10.2）% and（15.1±
13.4）%，respectively，at the final concentration of 0.5 mg/mL. There were significant differences in lipid-lowering rate between the
extracts of these 4 compositae plants and simvastatin in vitro（P＜0.01）. Conclusion：The four plants of C. blinii，A. adenophora，B.
tripartita，and T. diversifolia have significant in vitro lipid-lowering activities，which are worth further study.

Key words: Compositae, in vitro lipid-lowering activity, a model of HepG2 cells, Conyza blinii, Ageratina adenophora

CLC Number:

R285.5

Lang Lijuan, Cui Shujun, Zhu Qijie, Yang Li, Wang Ying, Jiang Bei, Xiao Chaojiang. Study on in vitro Lipid-Lowering Activity of 33 Compositae Plants from West Yunnan[J]. Journal of Dali University, 2022, 7(2): 1-5.

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