Study on the Relationship between Vaginal
Microenvironment， Interleukin-4 and High-Risk HPV Infection of the Cervix

Abstract

Abstract:

Objective： To study the relationship between vaginal microenvironment， interleukin-4（IL-4） and high-risk human papilloma virus（HR-HPV） infection of the cervix. Methods： From December 2018 to December 2019， 85 patients of childbearing age with cervical HR-HPV infection who were admitted to the First Affiliated Hospital of Dali University were selected as the observation group（Group A）， and 83 patients with cervical HPV-negative physical examination during the same period were selected as the control group（Group B）. The HR-HPV infections in women of different ages were compared， the vaginal microenvironment and the level of IL-4 in vaginal lavage fluid were detected， and the relationship between HR-HPV infection and common vaginitis was analyzed by multivariate Logistic regression analysis. Results： Among HR-HPV infected persons， the infection rate of persons ≤25 years old and >45 years old was higher than that of persons 26 to 45 years old， and the difference was statistically significant （P＜0.05）. There were significant differences in vaginal microenvironmental indicators and the level of IL-4 in vaginal lavage fluid between Group A and Group B（P＜0.05）. The positive rates of trichomonas vaginitis and bacterial vaginosis in Group A were higher than those in Group B， and the differences were statistically significant（P<0.05）. Logistic regression analysis showed that Lactobacillus，trichomonas vaginitis， bacterial vaginosis， and leukocyte esterase were all independent risk factors for HR-HPV infection. Conclusion： There is age distribution characteristics in HR-HPV infection. The vaginal microenvironment and the increase of IL-4 level in vaginal lavage fluid are closely related to its classification.

Key words:

vaginal microenvironment">； vaginal flora">； interleukin-4">； high-risk human papilloma virus

CLC Number:

Zhou Yuanyuan, Du Lingying, Qi Mengjuan, Guo Ying.

Study on the Relationship between Vaginal Microenvironment， Interleukin-4 and High-Risk HPV Infection of the Cervix [J]. Journal of Dali University, 2022, 7(2): 57-61.

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Study on the Relationship between Vaginal Microenvironment， Interleukin-4 and High-Risk HPV Infection of the Cervix

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