The Value of Quantitative CT in Bone
Mineral Density Measurement of Patients with Chronic Kidney Disease

Abstract

Abstract: Objective： To investigate the value of quantitative CT in measuring bone mineral density in patients with chronic kidney disease（CKD）. Methods： From January 2019 to December 2021， CKD patients（case group） diagnosed in Chongqing Changshou District People's Hospital and healthy volunteers（control group） who underwent bone mineral density examination at the same time were selected as the research objects. The bone mineral density was measured by dual-energy X-ray absorptimetry and quantitative CT. The research objects were divided into normal bone mass subgroup， low bone mass subgroup and osteoporosis subgroup according to the T value. According to the stage of CKD patients， the case group were divided into CKD stage 1-2 subgroup， CKD stage 3 subgroup， CKD stage 4 subgroup and CKD stage 5 subgroup. The bone mineral density of each group was compared， and the diagnostic value of quantitative CT for osteoporosis in CKD patients was evaluated by the receiver operator characteristic curve（ROC curve）. Results： The overall differences of bone mineral density in different bone mass subgroups were statistically significant， and the differences between groups were also statistically significant（P<0.05）. There was a statistically significant difference in the overall bone mineral density between the control group and different CKD subgroups， and there was a statistically significant difference in the bone mineral density between CKD stage 4 subgroup， CKD stage 5 subgroup and the control group （P<0.05）. The ROC curve results showed that the sensitivity and specificity of quantitative CT in detectingbone mineral density for osteoporosis in CKD patients were 80.99% and 83.10%， respectively， with good diagnostic efficacy. Conclusion： Quantitative CT can be used to measure bone mineral density in CKD patients， which has high diagnostic value for osteoporosis in CKD patients.

Key words: font-family:Times New Roman, ">quantitative CTfont-family:Times New Roman, ">, font-family:Times New Roman, "> chronic kidney diseasefont-family:Times New Roman, ">, font-family:Times New Roman, "> bone mineral densityfont-family:Times New Roman, ">, font-family:Times New Roman, "> analysis of receiver operator characteristic curve

CLC Number:

Xia Wangxu, He Yongfang, Chen Xiaobo, Huang Chuanfen.

The Value of Quantitative CT in Bone Mineral Density Measurement of Patients with Chronic Kidney Disease [J]. Journal of Dali University, 2023, 8(2): 70-73.

References

〔1〕朱晓宇，姜丽丽，魏玉丹，等.尿酸与慢性肾脏病-矿物质和骨代谢异常的研究进展〔J〕.中国全科医学，2020，23（5）：511-515.

〔2〕 KIM K， SONG S H， KIM I J， et al. Is Dual-Energy Absorptiometry Accurate in the Assessment of Bone Status of Patients with Chronic Kidney Disease? 〔J〕. Osteoporos Int，2021，32（9）：1859-1868.

〔3〕 LALAYIANNIS A D， CRABTREE N J， FEWTRELL M， et al. Assessing Bone Mineralisation in Children with Chronic Kidney Disease： What Clinical and Research Tools Are Available? 〔J〕. Pediatr Nephrol，2020，35（6）：937-957.

〔4〕 LALAYIANNIS A D， CRABTREE N J， FERRO C J， et al. Routine Serum Biomarkers， but Ｎot Dual-Energy X-Ray Absorptiometry， Correlate with Cortical Bone Mineral Density in Children and Young Adults with Chronic Kidney Disease〔J〕. Nephrol Dial Transplant，2020，36（10）：

1872-1881.

〔5〕南京总医院，国家肾脏疾病临床医学研究中心.慢性肾脏病患者妊娠管理指南〔J〕.中华医学杂志，2017，97（46）：3604-3611.

〔6〕 KHAIRALLAH P， NICKOLAS T L， FUSARO M. How and Ｗhen to Assess Bone Mineral Density and Bone Quality in Chronic Kidney Disease Patients? 〔J〕. Nephrol Dial Transplant，2019，36（5）：774-776.

〔7〕 CHEN T Y， YANG J， ZUO L， et al. Relationship of Abdominal Aortic Calcification with Lumbar Vertebral Volumetric Bone Mineral Density Assessed by Quantitative Computed Tomography in Maintenance Hemodialysis Patients〔J〕. Arch Osteoporos，2022，17（1）：24.

〔8〕 KIM H， LEE J， LEE K B， et al. Low Bone Mineral Density Is Associated with Coronary Arterial Calcification Progression and Incident Cardiovascular Events in Patients with Chronic Kidney Disease〔J〕. Clin Kidney J，2021，15（1）：119-127.

〔9〕邢玥，林珊.慢性肾脏疾病：矿物质和骨代谢疾病的发病机制及治疗研究进展〔J〕.山东医药，2021，61（18）：112-115.

〔10〕 PAGGIOSI M A， DEBONO M， WALSH J S， et al. Quantitative Computed Tomography Discriminates between Postmenopausal Women with Low Spine Bone Mineral Density with Vertebral Fractures and Ｔhose with Low Spine Bone Mineral Density Only： The SHATTER Study〔J〕. Osteoporos Int，2020，31（4）：667-675.

〔11〕 EVENEPOEL P， CUNNINGHAM J， FERRARI S， et al. Diagnosis and Management of Osteoporosis in Chronic Kidney Disease Stages 4 to 5D： A Call for a Shift from Nihilism to Pragmatism〔J〕. Osteoporos Int，2021，32（12）：

2397-2405.

〔12〕 SOTOMAYOR C G， BENJAMENS S， GOMES-NETO A W， et al. Bone Mineral Density and Aortic Calcification： Evidence for a Bone-Vascular Axis after Kidney Transp-lantation〔J〕. Transplantation，2021，105（1）：231-239.

〔13〕 LINK T M， KAZAKIA G. Update on Imaging-Based Measurement of Bone Mineral Density and Quality〔J〕. Curr Rheumatol Rep，2020，22（5）：13.

〔14〕 ZHOU Y， LIU S， WANG X， et al. Implications of Gender-Based Variabilities in Bone Mineral Density and Hemoglobin Levels〔J〕. BMC Musculoskelet Disord，2021，

22（1）：645.

〔15〕 CHIU H W， HOU Y C， LU C L， et al. Cinacalcet Improves Bone Parameters through Regulation of Osteoclast Endoplasmic Reticulum Stress， Autophagy， and Apoptotic Pathways in Chronic Kidney Disease-Mineral and Bone Disorder〔J〕. J Bone Miner Res，2022，

37（2）：215-225.

〔16〕 JUH?魣SZ B， GULY?魣S K， HORV?魣TH ?魣， et al. Peripheral Quantitative Computed Tomography in the Assessment of Bone Mineral Density in Anti-TNF-Treated Rheumatoid Arthritis and Ankylosing Spondylitis Patients〔J〕. BMC Musculoskelet Disord，2021，22（1）：817.

[1]	Ma Yongjie, Li Weiqi, Wu Chunting, Huang Xinhui, Zhou Xinyu, Ya Fuli, . The Protective Effect and Mechanism of Panax notoginseng Saponins on ox-LDL-Induced Platelet Apoptosis [J]. Journal of Dali University, 2023, 8(2): 1-7.
[2]	Zhu Qianwei, Yang Hua, Qian Kai, Li Dan, Xia Conglong. Study on the Mechanism of Compound Longxuejie Capsules in Treating Coronary Heart Disease Based on Network Pharmacology and Molecular Docking [J]. Journal of Dali University, 2023, 8(2): 8-18.
[3]	He Siyue, Tang Ziyun, Liu Heng, Zhang Chenggui, Zhou Wen, Bi Ziying, Zhou Yue. Inhibition of K562 Cell Proliferation by p53 Protein Regulated by Periplaneta americana Extract CⅡ-3 [J]. Journal of Dali University, 2023, 8(2): 19-23.
[4]	Li Weiqian, Chen Yiming, Zhang Wenting, Su Yingzhen, Shuai Hongyan, Yu Xin. Bioinformatics-Ｂased Analysis and Screening of Differentially Expressed Genes in Pancreatic Cancer [J]. Journal of Dali University, 2023, 8(2): 24-30.
[5]	Cheng Mingjing, Yan Ping, Fan Yujuan, Zhao Weidong. Bioinformatic Analysis of Differentially Expressed Genes in the Patients Infected with Helicobacter pylori [J]. Journal of Dali University, 2023, 8(2): 31-35.
[6]	Yao Qiuyan, Wu Zesheng, Shi Rognjie, Yang Liwei. Analysis of Short-Term Prognostic Factors in Alcoholic Liver Disease-Related Acute-on-Chronic Liver Failure [J]. Journal of Dali University, 2023, 8(2): 36-41.
[7]	Song Qiuling, Dai Jiao. The Expression of Serum Progranulin in Patients with Graves Disease and Its Correlation with IL-17 and IL-10 [J]. Journal of Dali University, 2023, 8(2): 42-45.
[8]	Cheng Wei, Shi Haibin, Cun Xiangnong, Ai Kewei, Fan Jiaju, Yang Jiwu. A Comparative Study of the Clinical Efficacy of Endoscopic Thyroidectomy via the Thoracic-Breast Approach and Open Thyroidectomy [J]. Journal of Dali University, 2023, 8(2): 46-50.
[9]	Chen Huaqiu, Chen Xingyou, Wang Guangming. Study of the Distribution of High-Risk Human Papilloma Virus Subtypes in Liangshan Region， Sichuan Province [J]. Journal of Dali University, 2023, 8(2): 51-55.
[10]	Tian Tian, Yan Jing, Dai Jiao. Changes of MiR-1281 and MiR-122 in Peripheral Blood of DR Patients and Their Relationship with the Severity of Retinopathy [J]. Journal of Dali University, 2023, 8(2): 56-61.
[11]	Sun Xiaomei, Mei Wen, He Bing, Luo Zhonggui, Sun Ruli, Xiong Wei, Zhao Yi. Expression and Prognostic Significance of Ki-67， Bcl-6， Bcl-2 and TEFM in Diffuse Large B Cell Lymphoma [J]. Journal of Dali University, 2023, 8(2): 62-69.
[12]	Dong Liwen, Wang Caihong, Zou Tuanbiao. Comparison of Three Detection Methods for Urinary Sediment [J]. Journal of Dali University, 2023, 8(2): 74-77.
[13]	Ni Zhaolin, Zuo Shunwu, Liu Hongyan, Ai Zhiqiong, Nong Luming, Zhao Qiufang, Wu Qiang. Epidemiological Characteristics and Trend Prediction of Influenza in Yuxi City from 2010 to 2019 [J]. Journal of Dali University, 2023, 8(2): 78-83.
[14]	Miao Zhifei, Huang Zhaodan, Chen Yanqing, Chang Yanping. Application of Drawing the Vascular Site Map under B-Ultrasound in Rope Ladder Puncture [J]. Journal of Dali University, 2023, 8(2): 84-87.
[15]	Zhu Xiaoli, Shi Tingting, Zhang Likun, Wei Yanni, Li Ting, Zhang Xiaoling. Application Analysis of Individualized Follow-Up Guidance Based on Network Platform in Patients with Basal Insulin [J]. Journal of Dali University, 2023, 8(2): 88-92.

The Value of Quantitative CT in Bone Mineral Density Measurement of Patients with Chronic Kidney Disease

PDF (PC)

Knowledge

Abstract

Cite this article

share this article

References

Related Articles 15

Recommended Articles

Metrics

Comments