Propensity Score Matching Analysis of
Postoperative Radiotherapy in Patients with Stage ⅢA/N2 Non-Small Cell Lung Carcinoma

Abstract

Abstract: Objective： Propensity score matching（PSM） was used to evaluate the effect of postoperative radiotherapy in patients with stage ⅢA/N2 non-small cell lung carcinoma（NSCLC）. Methods： A total of 1 832 patients with stage ⅢA/N2 NSCLC undergoing surgical resection combined with adjuvant chemotherapy were collected from the SEER database. Baseline characteristics of the two groups were compared by χ2 test， overall survival（OS） and lung cancer-specific survival（LCSS） of the two groups were evaluated by Kaplan-Meier curve， and prognostic factors were analyzed by COX regression model. Results： Among the 1 832 patients， 906 patients received postoperative radiotherapy（included in the postoperative radiotherapy group） and 926 patients did not receive postoperative radiotherapy（included in the control group）. There was no statistical significance in OS and LCSS between the two groups after PSM（P>0.05）. Univariate COX regression analysis showed that age<65 years old， female， clinical stage Ⅰ-Ⅱ， tumor diameter≤3 cm were protective factors for survival and prognosis（HR<1， P<0.05）. Multivariate COX regression analysis showed that age<65 years old， number of lymph node dissection ≥4 could better predict OS and LCSS（HR<1，Ｐ<0.05）. In the postoperative radiotherapy subgroup， patients with squamous cell carcinoma and age <65 years had worse LCSS. Conclusion： The addition of postoperative radiotherapy did not improve the prognosis of stageⅢA/N2 NSCLC patients treated with surgical resection combined with adjuvant chemotherapy.

Key words: font-family:Times New Roman, ">non-small cell lung carcinomafont-family:Times New Roman, ">；font-family:Times New Roman, ">stage font-family:Times New Roman, ">Ⅲfont-family:Times New Roman, ">A/N2font-family:Times New Roman, ">；font-family:Times New Roman, ">postoperative radiotherapyfont-family:Times New Roman, ">；font-family:Times New Roman, ">propensity score matchingfont-family:Times New Roman, ">；font-family:Times New Roman, ">prognostic factors

CLC Number:

Wu Maofang, Shi Wen, Xiao Shouyong, Cai Jingjing, Liu Zengping, Fang Hong.

Propensity Score Matching Analysis of Postoperative Radiotherapy in Patients with Stage ⅢA/N2 Non-Small Cell Lung Carcinoma [J]. Journal of Dali University, 2023, 8(8): 64-70.

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Propensity Score Matching Analysis of Postoperative Radiotherapy in Patients with Stage ⅢA/N2 Non-Small Cell Lung Carcinoma

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