Abstract: Objective: To analyze the results of allergen detection in patients with atopic dermatitis （AD） in Dali region, providing
epidemiological data and clinical diagnostic basis for the prevention and treatment of AD in this region. Methods: Clinical data of 824
AD patients were collected, and the results of serum specific immunoglobulin E （IgE） detection for allergens were statistically
analyzed. Results: Among the 824 AD patients, the positive rate of IgE was 35.44%, with 22.94% having one positive item and 12.50%
having two or more positive items. The top five positive rates for inhalant allergens were dust mite mix, mugwort, common ragweed, tree
mix, and cockroach; for food allergens, the top five were egg white, milk, crab, soybean, and peanut. The top three positive allergens
varied among different age groups. In the infants and toddlers group （0-2 years）, they were milk, egg white, and beef; in the preschool
children group（ 3-6 years）, they were dust mite mix, egg white, and mugwort/common ragweed/tree mix; in the school-age adolescents
group （7-18 years）, they were dust mite mix, cockroach/mugwort, crab/common ragweed; in the young adults group （19-45 years）,
they were dust mite mix, cockroach, and mugwort; in the middle-aged and elderly group （45 years and above）, they were mugwort/
common ragweed, dust mite mix, and tree mix. With increasing age, the positive rate of food allergens gradually decreased. Differences
in the positive rates of egg white, milk, peanut, crab, soybean, beef, lamb, dust mite mix, mugwort, cockroach, cat hair, house dust, and
hops among patients in different age groups were statistically significant （P<0.05）. The reaction intensity of specific IgE to allergens
was mainly in grades 1-3. Conclusion: The positive rate of serum specific IgE in AD patients is relatively high, mainly mixed type.
Various allergens show significant differences in distribution among different age groups, providing guidance for the prevention and
treatment of AD in the local area.

Key words: atopic dermatitis, specific IgE antibody, allergen, Western blotting