Abstract:

Objective: To explore the relationship between Dali women with cervical human papillomavirus（HPV）infection and
disease subtypes and epidemiological characteristics of the cervix. Methods: Samples of the obstetrics and gynecology outpatients from
July 2011 to September 2014 at the Affiliated Hospital of Dali University were collected. 2 053 cases with an average age of 39.46
years were undertaken the detection of subgenotypes diversion by gene amplification and hybridization techniques. TCT and
pathological examination method was used to the type of lesion detection. HPV-positive patients were collected according to the age,
nationality and profession. Results: Positive cases were 308 and the positive rate was 15.00%. 14 kinds of high-risk were detected:
HPV16（28.90%）, HPV52（21.75%）, HPV58（12.99%）, HPV18（10.39%）, HPV68（4.22%）, HPV31（2.27%）, HPV66（3.25%）,
HPV33（5.19%）, HPV39（5.52%）, HPV53（4.55%）, HPV59（1.62%）, HPV56（0.65%）, HPV35（1.62%）, HPV51（2.60%）. 5
kinds of low-risk types were: HPV45, HPV42, HPV6, HPV11,81（cp8304）. HPV infection in cervical lesions single positive rate were
21.95%（TBS）, 50%（pathology）, and multiple infections cervical lesions positive rate 4.88%（TBS）, 9.38%（pathology）. 122
positive cases were recorded nationalities, including 81 Bai cases（66.39%）, 27 Han, 6 Yi, 4 Lisu, 2 Tibetan, 1 Muslim and 1 Naxi.
Bai women were detected eight kinds of subgenotypes. The occupations were farmers（52.70%）and non-farmers（employees, civil
servants and freelancers, etc.）（47.30%）. Conclusion: Most common types of HPV infection in Dali were 16, 52, 58, 18. And multiple
infection did not increase the incidence of cancer. HPV cases constituted a relatively high age group of 30 to 52 years old, and a high
positive rate is ≥62 years of age. The common genetic subtypes in Bai women were HPV type of 52, 16, 58, 18. HPV infection with
certain subtypes were characterized by geography, age, and ethnic characteristics.

Key words: human papillomavirus infection, cervical lesions, subtypes, pathology, cervical cytology