Efficacy Analysis of Caffeine Citrate on Primary Apnea in Premature Infants

Abstract

Abstract:

Objective: To investigate efficacy and safety of caffeine citrate for treating primary apnea in premature infants. Methods:
A retrospective analysis was conducted among clinical data of 92 cases of apnea in premature infants of 27-32 weeks in NICU during
November 2014 to October 2015. They were divided into two groups: observation group of caffeine citrate treatment（n=52）and the
control group of aminophylline treatment（n=40）. A comparison of the effectiveness of two apnea treatment and adverse reactions
incidence rate of tachycardia, hyperglycemia, irritability, bloating and gastric retention were done. Results: The clinical total effective
rate of the observation group was 90.4%, which was 70.0% higher than the control group. The difference was statistically significant
（P<0.05）. The rate of tachycardia, hyperglycemia, irritability, bloating, gastric retention during treatment of the observation group was
lower than the control group（P<0.05）. Conclusion: Caffeine citrate has significant effect on treating premature infants of primary
apnea, reducing the incidence of apnea, causing fewer adverse events and improving prognosis.

Key words: caffeine citrate, premature infants, low-birth-weight children, apnea

CLC Number:

R722.12

Yang Jie, Yang Xiuling, Qi Huixian, Shu Lei. Efficacy Analysis of Caffeine Citrate on Primary Apnea in Premature Infants[J]. , 2017, 2(2): 61-63.

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