Associations of IFN-γ Gene Polymorphism with Dilated Cardiomyopathy

›› 2017, Vol. 2 ›› Issue (8): 28-30.

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Associations of IFN-γ Gene Polymorphism with Dilated Cardiomyopathy

（1. Department of Pediatrics, The First Affiliated Hospital of Dali University, Dali, Yunnan 671000, China；2. Ultrasonic Department,
The First Affiliated Hospital of Dali University, Dali, Yunnan 671000, China；3. Department of Laboratory, The First Affiliated
Hospital of Dali University, Dali, Yunnan 671000, China；4. Pre-clinical College, Dali University, Dali, Yunnan 671000, China）

Received:2016-03-24 Revised:2017-03-26 Online:2017-08-15 Published:2017-08-15

Abstract

Abstract:

Objective：To investigate the relationship between mononucleotide's polymorphism of IFN-γ gene's 874 site and the
susceptibility to dilated cardiomyopathy. Methods：In this case-control study, we have collected venous blood of 113 patients with
DCM（patients group）and of 100 healthy Han adults（control group）from the first affiliated hospital of Dali University. PCR-SSP
technology and agarose gel electrophoresis were applied to detect mononucleotide's IFN-γ +874T/A polymorphism of the two groups.
Results：There were significant differences between the patient group whose IFN-γ +874TT genotypic frequency distribution was
30.97% and the health control group with 8.00%（χ2=17.631，P<0.001）. The distributive frequencies of T allele in the patient group
and control group were 40.27% and 22.00% respectively. There were statistically significant differences between them（χ2=16.352，P<
0.001）. Conclusion：There may be a close relationship between IFN-γ +874A/T polymorphism and the susceptibility to DCM.

Key words: dilated cardiomyopathy, IFN-γ, gene polymorphism

CLC Number:

R542.2

Zhou Li, Chen Haiyan, Kong Shan, Cheng Jiamao. Associations of IFN-γ Gene Polymorphism with Dilated Cardiomyopathy[J]. , 2017, 2(8): 28-30.

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Associations of IFN-γ Gene Polymorphism with Dilated Cardiomyopathy

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