The Relationship between Endothelial Nitric Oxide Synthase rs1799983 Gene Polymorphism and
Blood Pressure

Abstract

Abstract:

Objective：To explore the relationship between endothelial nitric oxide synthase（eNOS）rs1799983 polymorphism and
blood pressure. Methods：All employees including the retired of a factory in Dali were enrolled in the study. A standardized
questionnaire was distributed to collect information on alcohol consumption, smoking habits and use of medications. And then the
genotypes were categorized by SNaPshot method. Results：The frequencies of rs1799983 GG, GT and TT were 80.3%, 19.0% and
0.7% respectively. There was no significant difference in genotypes and alleles between participants with normal blood pressure and
hypertensive patients（P≥0.21）. However, T allele carriers（GT + TT）compared with GG homozygotes had a significantly higher
systolic and pulse pressure both before and after adjusted for covariates（P≤0.04）. It was found that significant interaction between
rs1799983 polymorphism and low- density lipoprotein cholesterol（LDL- C）had an effect on pulse pressure（Pint = 0.04）. Pulse
pressure of T allele carrier was significantly higher than GG homozygotes as LDL- C levels increased. Conclusion：The eNOS
rs1799983 polymorphism may be associated with blood pressure and affected by LDL-C levels.

Key words: nitric oxide synthase 3, polymorphism, genetics, blood pressure

CLC Number:

R544

Liu Yang, Zhang Qingtao, Meng Xiangzhi, Hu Naiqing, Deng Quanliang, Li Lihua. The Relationship between Endothelial Nitric Oxide Synthase rs1799983 Gene Polymorphism and
Blood Pressure[J]. , 2017, 2(8): 23-27.

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