Effects of Ethanol Extracts of Blaps rynchopetera Fairmaire on Proliferation of Human Embryonic Lung
Diploid Fibroblast

Abstract

Abstract:

〔Abstract〕Objective: To study the inhibitory effects of three ethanol extracts of Blaps rynchopetera Fairmaire（A, B, C）on proliferation
of human embryonic lung diploid fibroblast, and to compare the inhibition effects of the three extracts. Methods: Human embryonic
lung diploid fibroblast were incubated with extract A, B and C of 3.9~1 000.0 μg/mL in vitro. MTT was used to detect the effects of three
ethanol extracts of Blaps rynchopetera Fairmaire on proliferation of cells. Result: High concentrations of three ethanol extracts of Blaps
rynchopetera Fairmaire significantly inhibited the growth of human embryonic lung diploid fibroblast and showed a time-dose-effect
dependence. At the concentration of 1 000.0 μg/mL and after 72 h, the inhibitory rates of A, B and C on the cells reached the highest,
which were 49.87%, 50.13%, and 42.34%, respectively. There were no significant differences in the proliferation activity of A, B and
C. Conclusion: The ethanol extracts of Blaps rynchopetera Fairmaire can significantly inhibit proliferation of human embryonic lung
diploid fibroblast, and the inhibitory effects of A, B and C on the cells were not significant.

Key words: 〔Key words〕Blaps rynchopetera Fairmaire, human embryonic lung diploid fibroblast, cell proliferation

CLC Number:

R965

Zhang Handan, Wu Daoxun, Zhang Haizhu, Li Yang. Effects of Ethanol Extracts of Blaps rynchopetera Fairmaire on Proliferation of Human Embryonic Lung
Diploid Fibroblast[J]. , 2018, 3(10): 18-21.

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