Chemical Constituents of the Fruits of Wild Crataegus scabrifolia

Abstract

Abstract: 〔Abstract〕Objective: To study the chemical constituents of Crataegus scabrifolia（Franch.）Rehd. and their lipid-lowering activities.
Methods: The compounds were isolated and purified by column chromatography padded with silica gel and Sephadex LH-20, and their
structures were identified based on the comprehensive analyses of the physicochemical properties and spectral data. The lipid-lowering
activity in vitro was evaluated by cellular model of high-fat HepG2. Results: Six compounds were obtained from the 95% ethanol extract
of the fruits of wild C. scabrifolia and identified as benzoic acid（1）, 2-hydroxybutanedioic acid dimethyl ester（2）, 2-hydroxy-succinic
acid 1-methyl ester（3）, β-sitosterol（4）, daucosterol（5）, and quercetin（6）. Compounds 2-5 showed no significant lipid reduction at
200 μmol/L concentration. Conclusion: This was the first report on compounds 2 and 3 from the plants of Genus Crataegus, and
compound 1 was isolated from C. scabrifolia for the first time. Compounds 2-5 had no lipid-lowering activity in vitro.

Key words: 〔Key words〕Crataegus scabrifolia, chemical constituents, 2-hydroxy succinic acid

CLC Number:

R284.1

Zhu Qijie, Lang Lijuan, Jiang Bei, Shen Yi, Wang Ying, Xiao Chaojiang. Chemical Constituents of the Fruits of Wild Crataegus scabrifolia[J]. Journal of Dali University, 2021, 6(4): 7-9.

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