Journal of Dali University

Chemical Constituents of Aerial Parts of Ternstroemia gymnanthera

Liu Ming, Li Huaxuan, Shen Yi, Xiao Chaojiang, Jiang Bei

2021, 6(4): 1-3.

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〔Abstract〕Objective: To study the chemical constituents of aerial parts of Ternstroemia gymnanthera（wight et Arn.）Beddome.
Methods: The chemical constituents of T. gymnanthera were isolated and purified by column chromatography padded with silica gel
and Sephadex LH-20. The structures of the compounds were identified based on the comprehensive analyses of the physicochemical
properties and modern spectral analysis techniques. Results: Five compounds were obtained from ethyl acetate part of 95% ethanol
extract of aerial parts of T. gymnanthera and identified as betulinic acid（1）, 3-epiursolic acid（2）, ursonic acid（3）, α-spinasterol-
β-D-glucopyranoside（4）, and butyl-2-（3, 4-dihydroxyphenyl）acetate（5）. Conclusion: Compounds 2, 3 and 5 were isolated from
the genus Ternstroemia for the first time.

Chemical Constituents of Flavonoids from Medicinal Plant Gentiana yunnanensis

Wang Tian, Ye Zuyue, Yang Huiyun, Wang Le, Wang Fushen

2021, 6(4): 4-6.

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〔Abstract〕Objective: To study the chemical constituents of medicinal plant Gentiana yunnanensis. Methods: The chemical
compounds were isolated from the 95% ethanol extract of G. yunnanensis by the techniques of column chromatography including AB-8
macroporous adsorptive resins, silica gel, Sephadex LH-20, middle chromatogram isolated gel（MCI）and octadecylsilane chemically
bonded silica（ODS）, and the structures of the compounds were identified based on modern spectroscopic techniques. Results: Seven
flavonoids were isolated from G. yunnanensis and identified as isoorientin（1）, vitexin（2）, apigenin-7-O-β-D-glucopyranoside（3）,
luteolin-7-O-β-D-glucopyranoside（4）, naringenin（5）, kaempferol（6）and puerarin（7）. Conclusion: Seven compounds were all
isolated from this plant for the first time, among which compound 4 was isolated from this genus for the first time.

Chemical Constituents of the Fruits of Wild Crataegus scabrifolia

Zhu Qijie, Lang Lijuan, Jiang Bei, Shen Yi, Wang Ying, Xiao Chaojiang

2021, 6(4): 7-9.

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〔Abstract〕Objective: To study the chemical constituents of Crataegus scabrifolia（Franch.）Rehd. and their lipid-lowering activities.
Methods: The compounds were isolated and purified by column chromatography padded with silica gel and Sephadex LH-20, and their
structures were identified based on the comprehensive analyses of the physicochemical properties and spectral data. The lipid-lowering
activity in vitro was evaluated by cellular model of high-fat HepG2. Results: Six compounds were obtained from the 95% ethanol extract
of the fruits of wild C. scabrifolia and identified as benzoic acid（1）, 2-hydroxybutanedioic acid dimethyl ester（2）, 2-hydroxy-succinic
acid 1-methyl ester（3）, β-sitosterol（4）, daucosterol（5）, and quercetin（6）. Compounds 2-5 showed no significant lipid reduction at
200 μmol/L concentration. Conclusion: This was the first report on compounds 2 and 3 from the plants of Genus Crataegus, and
compound 1 was isolated from C. scabrifolia for the first time. Compounds 2-5 had no lipid-lowering activity in vitro.

Study on the Synthesis and Reaction Conditions of Secologanol Acylation Products

Wang Le, Yang Zongbin, Wang Tian, Guo Haihui, Wang Fusheng

2021, 6(4): 10-13.

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〔Abstract〕Objective: To improve the anti-Alzheimer′s disease activities of secoiridoid glycoside Secologanol. The aim of this study
is to modify the structure of Secologanol and synthesize its corresponding acylation products, so as to enhance the structural stability
and activity of its derivatives and lay a foundation for further structural modification. Methods: Secologanol was acylated with acetic
anhydride and benzoyl chloride respectively by controlling the equivalent of acylating agent and its reaction time. Results: The
acetylation and benzoylation products could be synthesized quickly and efficiently. Conclusion: New Secologanol acylation products 1,
3, 4 and 5 are synthesized. Besides, the reaction has good reproducibility with high yield and stable structure of acylation products,
which can be used for further structural modification and activity test.

In vitro Lipid-Lowering Activity of 18 Leguminosae Plants in West Yunnan

Lang Lijuan, Jiang Bei, Cui Shujun, Zhu Qijie, Dong Xiang, Xiao Chaojiang

2021, 6(4): 14-17.

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〔Abstract〕Objective: To explore the in vitro lipid-lowering activity of 18 Leguminosae plants in west Yunnan, and to provide a
scientific basis for the discovery of novel hypolipidemic drugs from plants. Methods: 18 Leguminosae plants were extracted with
75% ethanol by heat reflux. High-fat HepG2 cell model was used to screen the lipid-lowering activity of the crude extracts in vitro,
and the bioactive results were evaluated by lipid-lowering rates. Results: 13 plant extracts showed lipid-lowering activity in
different degrees. Among them, the aerial parts of Glycyrrhiza yunnanensis, the whole herb of Lespedeza cuneata, the underground
parts of Astragalus polycladus var. nigrescens and the aerial parts of Bauhinia brachycarpa, showed significant activities to inhibit
lipid accumulation, with inhibition ratios of （21.6±3.9）% , （19.6±10.0）% , （17.8±1.9）% and （15.3±4.6）% , respectively, at
concentration of 0.5 mg/mL. Conclusion: The aerial parts of Glycyrrhiza yunnanensis, the whole herb of Lespedeza cuneata, the
underground parts of Astragalus polycladus var. nigrescens and the aerial parts of Bauhinia brachycarpa, have good lipid-lowering
activity, which is worth a further study.

Effects of Active Extracts from Periplaneta americana on Treating Hepatic Fibrosis in Rats by Gastric and Intestinal Administration#br#

Gu Ting, Yang Yongshou, Xie Jingjing, Xiao Peiyun

2021, 6(4): 18-22.

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〔Abstract〕Objective: To study the effects of active extract of Periplaneta americana（PA-B）on liver fibrosis induced by carbon
tetrachloride in rats by gastric and intestinal administration. Methods: According to the body weight, male SD rats were randomly
divided into 8 groups, including the control group, the model group, enteric-soluble excipient group, gastric-soluble excipient group,
the positive drug group, the active pharmaceutical ingredients（APIs）group, enteric drug group and gastric drug group. Except for the
control group, the other groups were intraperitoneally injected with 40% carbon tetrachloride oil, the control group was injected with the
same dose of olive oil. After successful modeling, each group was given corresponding drugs. The liver tissues were stained by
hematoxylin-eosin（HE）and Masson, and the pathological changes were observed under the microscope. The microplate method was
used to determine alanine aminotransferase（ALT）and aspartate aminotransferase（AST）; the enzyme-linked immunosorbent assay
（ELISA）was applied to measure serum liver fibrosis indexes hyaluronic acid（HA）, laminin（LN）, procollagen type Ⅲ（PC-Ⅲ）and
collagen type Ⅳ（Col-Ⅳ）; the content of hydroxyproline（HYP）in liver tissue was measured by the alkaline hydrolysis method.
Results: Compared with the control group, the model group had more collagen fibers and more false lobules; compared with the model
group, the levels of various detection indexes in the positive drug group, the APIs group, enteric drug group and gastric drug group
decreased, and the differences were statistically significant（P < 0.05 or P < 0.01）. There was no statistical significance in each index
among positive drug group, APIs group, enteric drug group and gastric drug group（P＞0.05）. Conclusion: PA-B and related
preparations could effectively improve liver fibrosis in rats, but there was no significant difference in the therapeutic effect of PA-B on
liver fibrosis in rats by gastric and intestinal administration.

Effects of Periplaneta americana Extracts on Apoptosis of Hippocampal Neuronal Cell HT22

Yang Li, Zhu Jianhua

2021, 6(4): 23-26.

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〔Abstract〕Objective: To observe the effects of components extracted from Periplaneta americana with different solvents on the
apoptosis of mouse hippocampal neuronal cell lines HT22 cells cultured in vitro. Methods: Water extract, 40% alcohol extract, 60%
alcohol extract, 95% alcohol extract and crude extract of Periplaneta americana were prepared. And the above five components were
used to intervene in the HT22 cells cultured in vitro. The solvent control group and Periplaneta americana extract groups with final
concentrations of 60, 80, 100 and 120 μg/mL were set for each component. Flow cytometry was used to detect the effect of each
component of Periplaneta americana extract on HT22 cell apoptosis. Results: Compared with the solvent control, the crude extract and
the 95% alcohol extract of Periplaneta americana promoted the apoptosis of HT22 cells, and the differences were statistically
significant（P < 0.05）; the water extract and the 40% alcohol extract of Periplaneta americana inhibited apoptosis of HT22 cells, and
the differences were statistically significant（P < 0.05）; 60% ethanol extract of Periplaneta americana has no obvious effect on cell
apoptosis, the differences were not statistically significant（P>0.05）. Conclusion: The different components of Periplaneta americana
extract have different effects on the apoptosis process of mouse hippocampal neurons.

Analysis of Factors Influencing Medication Compliance of Patients with Pulmonary Tuberculosis under Pharmaceutical Care Guidance#br#

Chen Yonggang , Luo Ji, Peng Jiangli, Liu Xing, Li Na, Chen Jie

2021, 6(4): 27-29.

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〔Abstract〕Objective: To explore the risk factors affecting medication compliance of patients with pulmonary tuberculosis. Methods:
The guidance of whole-course pharmaceutical care was given to tuberculosis patients and a questionnaire was established. The basic
information, treatment status, adverse reactions and other factors affecting medication compliance of 367 valid questionnaires were
statistically analyzed. Results: Among the 367 patients included in the study, 238 patients（64.85%）had good compliance and
129 patients（35.15%）had poor compliance. Awareness of the disease and hyperuricemia were independent risk factors for medication
compliance. Conclusion: Medication compliance of patients with pulmonary tuberculosis is affected by many factors. After
pharmaceutical intervention, the knowledge of the disease and the occurrence of adverse reactions（hyperuricemia）are still the most
important factors influencing medication compliance. Individualized pharmaceutical services provided by pharmacists for tuberculosis
patients can significantly improve their medication compliance and enhance the treatment effect.

Effects of Klotho RNA Interference on Proliferation, Migration and Oxidative Stress in Human Aortic Vascular Smooth Muscle Cells#br#

Wei Jianhang, Liang Quan, Huang Shiqiong, Li Lihua

2021, 6(4): 30-35.

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〔Abstract〕Objective: To examine the effects of Klotho RNA interference on proliferation, migration and oxidative stress in human
aortic vascular smooth muscle cells（HA-VSMC）. Methods: Lentivirus was used to inhibit the expression of Klotho in HA-VSMC,
and the transfection efficiency was verified by fluorescence microscopy, fluorescence quantitative polymerase chain reaction and the
Western blot. CCK-8 method was used to detect cell proliferation, and Transwell method was used to detect cell migration. The
intracellular superoxide dismutase（SOD）and malondialdehyde（MDA）content was detected by the micro method. The relative
expressions of NOX1, NOX2, NOX3, NOX5 and DUOX2 were detected by fluorescence quantitative polymerase chain reaction.
Results: The expression of Klotho in HA-VSMC was significantly down-regulated after lentivirus transfection. Compared with the
blank control well, the decrease of Klotho expression could significantly increase the proliferation and migration of HA-VSMC, and
nicotinamide adenine dinucleotide phosphate oxidase（NOX1, NOX2, NOX3, NOX5 and DUOX2）mRNA expression were increased
significantly. Meanwhile, MDA levels increased significantly, while the SOD activity levels decreased significantly in cell lysates after
transfection. Conclusion: Klotho deficiency could promote HA-VSMC proliferation, migration and oxidative stress.

Application of Gray Histogram Image Processing Technology in Pathological Diagnosis of Gastric Adenocarcinoma#br#

Xu Xiaoyan, Mao Youbing, Fan Lifang, Zhang Yun

2021, 6(4): 36-39.

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〔Abstract〕Objective: To conduct a quantitative statistical analysis of pathological microscopic images of gastric adenocarcinoma
under the microscope by the digital medical image processing technology. Methods: The case group consisted of the pathological
images of 20 patients with gastric adenocarcinoma confirmed by gastroscopy biopsy from May to July in 2019 in Wuhu Hospital of
Chinese Traditional Medicine, and the control group included the outpatients with normal gastroscopy images within the same period.
The pathological images of the patients in the two groups were collected. Then the interval distributions of pixel points of gray-scale
pathological images were compared and analyzed. Results: the distribution of pathological image pixels in 101-150, 151-200 and 201-
255 was different between the control group and the case group, and the difference has statistical significance（P<0.01）. Conclusion:
Digital medical image processing technology can distinguish normal tissues from cancerous tissues, offering more objective basis for the
diagnosis of gastric adenocarcinoma and providing a research basis for the computer prescreen of pathological diagnosis of gastric
adenocarcinoma.

The Effect of Timing of Decortication of Pleural Fiberboard on the Treatment of Chronic Tuberculous Empyema#br#

Yang Wenrong, Li Zhuang, Li Aimin, Yang Lijie, Cha Jianyuan

2021, 6(4): 40-43.

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〔Abstract〕Objective: To discuss the effect of timing of pleural fiberboard stripping on the therapeutic effect of chronic tuberculous
empyema（CTE）. Methods: 160 patients with CTE were selected from June 2014 to June 2018 in the First Affiliated Hospital of Dali
University. All the patients were given pleural fiberboard stripping. According to the timing of surgery, patients were divided into the
early group（after 6 to 12-week anti-tuberculosis treatment）and the normal group（after 12-week anti-tuberculosis treatment）, with
80 patients in each group. Results: The operative time, pleural thickness, intraoperative blood loss, postoperative intubation time and
complication rate of the early group were significantly lower than those of the normal group, and the differences were statistically
significant（P<0.05）. The postoperative forced vital capacity（FVC）, forced expiratory volume in the first second（FEV1）and FEV1 ：
FVC of both the two groups were significantly higher than those before the operation; the FVC, FEV1, FEV1 ： FVC of the early group
were significantly higher than those of the normal group. The differences were statistically significant（P < 0.05）. The treatment
effective rate of the early group was higher than that of the normal group, with statistically significant difference （P < 0.05）.
Conclusion: Compared with the pleural decortication after 12-week anti-tuberculosis treatment, the surgery after 6 to 12-week anti-
tuberculosis treatment can effectively reduce surgical trauma and complications in patients with CTE. It is helpful to improve the
patient′s lung function and has better therapeutic effects, so it is worth for further clinical popularization.

Clinical Application of Vacuum Sealing Drainage in the Treatment of Chronic Leg Ulcers

Song Zheng, Li Aimin, Jin Zhuxuan, Zhao Limin

2021, 6(4): 44-47.

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〔Abstract〕Objective: To analyze the clinical effect of VSD in the treatment of chronic leg ulcers so as to provide a treatment basis for
clinical application. Methods: 50 patients with chronic leg ulcers in Weishan County People′s Hospital were selected. They were divided
into the control group and the observation group according to the type of treatment, with 25 patients in each group. The control group was
treated with dressings after surgical debridement, and the observation group was treated with VSD treatment after surgical debridement.
The nutritional status, the pain score, the preparation time of secondary suture, length of hospitalization, total hospitalization expenses,
the number of dressing changes after discharge and postoperative recurrence were compared between the two groups. Results: There was
no significant difference between the two groups in age, gender, wound site, history, wound area, initial treatment of wounds, duration of
antibiotic use, albumin levels, and PG-SGA score（P>0.05）. The pain degree of the observation group was less than that of the control
group on the 1st, 3rd and 5th day after treatment, and the difference was statistically significant on the 3rd and 5th day（P<0.05）. The
preparation time of secondary suture, and length of hospitalization and dressing changes after discharge in the observation group were less
than those in the control group, with statistically significant differences（P<0.05）. The total expenses of hospitalization in the observation
group were higher than that in the control group, and the difference was statistically significant（P<0.05）. After discharge, there were 4
cases of recurrent infection in the control group, and no cases of recurrent infection in the observation group, the difference was
statistically significant（P<0.05）. Conclusion: VSD has obvious effects in the treatment of chronic infectious wounds of the lower limbs,
but the cost is high, so the application should be individualized according to the wound condition of patients.

The Therapeutic Effects of Artificial Hip Arthroplasty on Femoral Intertrochanteric Fractures in the Elderly#br#

Wang Jiaming, Zhao Xiaoxiang

2021, 6(4): 48-52.

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〔Abstract〕Objective: To examine the application of artificial hip replacement in the treatment of the elderly patients with femoral
intertrochanteric fractures, and to evaluate its clinical effect. Methods: We retrospectively analyzed 46 cases of senior patients with
femoral intertrochanteric fractures who underwent the artificial joint replacement surgery. Among them, there were 12 males and 34
females, aged 79-93, with an average age of 85.2 years. All the patients were treated with hemi-arthroplasty. Results: 46 patients were
followed up for 3 to 12 months. Preoperative Harris score of hip joint function was（32.3 ± 4.5）; Harris score within 3 months after the
operation was（89.1 ± 2.2）; 6 months after the operation, 44 patients were excellent, 1 patient was good and 1 patient was fair in
function evaluation; the excellent and good rate was 97.83%（45/46）; there were no complications such as bedsore and venous
thrombosis in all patients. Conclusion: Artificial hip replacement is a safe and effective method for the treatment of unstable
intertrochanteric fractures in the elderly. After operation, patients can get out of bed early and bear weights. Within a short time,
patients can quickly recover and improve the function of hip joint, and avoid the serious complications of being forced to stay in bed
due to fractures. So, they can return back to the normal life before injury earlier and their quality of life can be improved.

Clinical Analysis of Long-Stem Total Hip Arthroplasty in the Treatment of Intertrochanteric Fracture with Femoral Head Necrosis in the Elderly#br#

Wang Hongping, Yang Xiaoqin, Tao Qifeng, Lan Yuping

2021, 6(4): 53-55.

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〔Abstract〕Objective: To discuss the clinical efficacy of long-stem total hip arthroplasty in the treatment of intertrochanteric fracture
with femoral head necrosis in the elderly. Methods: We retrospectively analyzed clinical efficacy of long-stem total hip arthroplasty in
the treatment of intertrochanteric fracture with femoral head necrosis in 21 patients in the Department of Othopedics in Panzhihua
Central Hospital from January 2015 to July 2018. Results: All the patients underwent the above-mentioned surgery at the same time,
and were followed up after surgery, with an average follow-up time of（14.0 ± 1.2）months. All patients had bone healing, and there
were no break or looseness in the internal fixation steel wire or cable; the position of the joint prosthesis was good without loosening or
sinking; the activity of hip joint was normal and improved significantly; all patients were satisfied with this treatment. Conclusion:
Long-stem total hip arthroplasty can solve the problems of fracture and necrosis of femoral head at the same time, avoid the pain of
patients caused by repeated operations, minimize the financial burden of patients and their families, and improve the satisfaction of
patients and their families with the treatment. So, it is an important and practical clinical method.

Clinical Analysis of 9 Patients with Tubal Stump Pregnancy after Laparoscopic Surgery

Yang Sili, Luo Wanxun, Wang Bin

2021, 6(4): 56-58.

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〔Abstract〕Objective：To explore the influencing factors and preventive measures of tubal stump pregnancy after laparoscopic surgery.
Methods：The clinical data of 9 patients with residual pregnancy after laparoscopic salpingectomy were analyzed retrospectively.
Results：The incidence rate of tubal stump pregnancy after surgery was 0.71%. In the first operation, 4 patients underwent laparoscopic
tubal stump vascular ligation and clipping, accounting for 44.44%, 3 patients underwent salpingectomy, accounting for 33.34%, and 2
patients underwent salpingectomy with absorbable suture, accounting for 22.22%. In this operation, all patients underwent tubal stump
resection or uterine angle suture repair of laparoscopic. Conclusion：The occurrence of tubal stump pregnancy after laparoscopic
surgery is closely related to the operation mode. Complete resection of the fallopian tube stump is the fundamental treatment mode. It is
necessary to improve the operation mode to reduce recurrent ectopic pregnancy.

Clinical Analysis of 78 kids of Otitis Media with Effusion Treated by Nasal Balloon Autoinflation

Gao Qiqiao, Yang Cong, Liu Wenbo, Lan Caijuan, Li Zhixiang

2021, 6(4): 59-61.

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〔Abstract〕Objective: To examine the clinical efficacy of nasal balloon autoinflation in the treatment of children with OME（otitis
media with effusion）. Methods: We selected 78 kids（126 ears）, aged from 3-14, who were diagnosed with OME but without chronic
rhinosinusitis, acute tonsillitis or adenoid hypertrophy in the outpatient department of People′s Hospital of Wenshan Zhuang and Miao
Autonomous Prefecture from January 2015 to January 2018. They were divided into the acute group with 34 kids（60 ears）and the
chronic group with 44 kids（66 ears）. All of the patients were treated with the method of nasal balloon autoinflation by asking them to
blow balloons through the nasal cavity twice or three times a day. Check-up was performed once a week to observe the curative effect,
and the maximum course of treatment was no more than 3 months. Results: In the acute group, 48 ears were cured（80.0% cure rate）,
8 ears got improvements（13.3% improvement rate）, and the treatment of 4 ears failed（6.7% ineffective rate）. In the chronic group, 47
ears were cured（71.2% cure rate）, 12 ears got improvements（18.2% improvement rate）, and the treatment of 7 ears failed（10.6%
ineffective rate）. In the acute group, 15 ears reached the standard of cure after 1-month treatment, 24 ears reached the standard of cure
after 2-month treatment, and 9 ears reached the standard of cure after 3-month treatment; 8 ears reached the improvement standard
after 3-month treatment. In the chronic group, 8 ears reached the healing standard after 1-month treatment, 14 ears reached the healing
standard after 2-month treatment, and 25 ears reached the healing standard after 3-month treatment; 12 ears reached the improvement
standard after 3-month treatment. Conclusion: Nasal balloon autoinflation is an effective indirect eustachian tube inflation method for
the treatment of OME in children, and has good clinical efficacy in the treatment of kids with acute and chronic OME.

Reliability Analysis of Neonatal Total Bilirubin Level Determined by the Transcutaneous Jaundice Detector

Huang Xunbin, Cheng Guoqiang, Qiu Huixian

2021, 6(4): 62-66.

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〔Abstract〕Objective: To evaluate the correlation and consistency of neonatal total bilirubin（TBIL）determined by transcutaneous
jaundice detector and automatic biochemistry analyzer. Methods: We retrospectively reviewed 383 neonates with hyperbilirubinemia
who were hospitalized in the Department of Neonatology, Longgang District Central Hospital of Shenzhen from June 2017 to June 2019.
According to TBIL values detected by automatic biochemistry analyzer, the patients were divided into the moderate jaundice group with
198 neonates, the severe jaundice group with 120 neonates, and the extremely severe jaundice group with 65 neonates. The TBIL
values were determined simultaneously by transcutaneous jaundice detector and automatic biochemistry analyzer. The correlation and
consistency of TBIL values determined by the two methods were analyzed by Spearman Correlation Coefficient and Bland-Altman
Scatter Plot. Results: The differences of TBIL values of the neonates in all the groups with different degrees of jaundice determined by
the two methods were significant（P＜0.01）. There was a significant positive correlation between TBIL values detected by
transcutaneous jaundice detector and values by automatic biochemistry analyzer（r = 0.973, P＜0.01）, but the consistency of TBIL
values detected by the two instruments was poor. Conclusion: Transcutaneous bilirubin（TCB）is a better tool used to monitor children
with moderate and severe jaundice, but for children with very severe jaundice, TCB alone is not enough and dynamic monitoring of
serum total bilirubin（STB）is also needed.

Correlative Analysis of the Epidemiological Characteristics and Course of Imported Dengue Fever in Kunming#br#

Liu Bing, He Hua, Zhang Yanling, Huang Ying

2021, 6(4): 67-70.

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〔Abstract〕Objective: To provide a theoretical basis for the early diagnosis, treatment, prevention and control of dengue fever based
on an analysis of the relevant data of imported dengue fever in Kunming City. Methods: Data were collected from patients with dengue
fever, the epidemiological characteristics were described, and the correlation between the course of disease and laboratory examination
indicators was analyzed. Results: There were a total of 143 patients with 101 males（70.63%）and 42 females（29.37%）, with an
average age of（34.72±9.79）years. Cases were reported from May to December. 91 patients（63.64%）were from Cambodia. The main
clinical manifestations were fever in 143 cases（100.00%）, muscle soreness in 123 cases（86.01%）, pharyngeal congestion in 109
cases（76.22%）, headache in 107 cases（74.83%）and fatigue in 88 cases（61.54%）. Laboratory results: 96 patients had leukopenia
（67.13%）, aspartate aminotransferase（AST）increased in 87 patients（60.84%）, and C-reactive protein（CRP）increased in 74
patients（51.75%）. The course of the disease was significantly correlated with white blood cells, platelets（PLT）, total bilirubin,
indirect bilirubin, gamma-glutamine transferase（GGT）and AST（P < 0.05）. Conclusion: Dengue fever in Kunming is mainly
imported from abroad and infected by common dengue fever. The course of the disease is positively correlated with total bilirubin,
indirect bilirubin, GGT and AST, but it is negatively correlated with white blood cells and PLT.

The Current Status and Influencing Factors of the Care Abilities of Patients with Chronic Heart Failure and Their Primary Caregivers

Zhang Yu, Li Lihua

2021, 6(4): 71-79.

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〔Abstract〕Objective: To evaluate the self-care abilities of patients with chronic heart failure（CHF）and their primary caregivers,
and analyze their respective influencing factors. Methods: A total of 61 inpatients with CHF and their primary caregivers in a hospital
were investigated by interviews and questionnaires. Results: The average score of Self-Care of Heart Failure Index for CHF patients
and their primary caregivers were（43.5±10.7）and（42.9±10.2）, respectively, and there was a significant positive correlation between
their scores. The patient′s levels of heart failure knowledge, admission times, education background and nationality were the primary
factors influencing his self-care ability. The primary caregiver′s level of heart failure knowledge, daily care time and self-awareness of
health condition, and the patient′s admission times were the major factors influencing his contribution to the patient′ self-care ability.
Conclusion: The self-care abilities of CHF patients and their primary caregivers′ contribution to patients′ self-care ability are
generally low, and the influencing factors are related to demographic and clinical characteristics.

A Mediation Model of Factors Influencing the Self-Management of Empty-Nest Elderly Patients with Hypertension

Zhang Hui, Zhang Bin

2021, 6(4): 80-84.

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〔Abstract〕Objective: To study the relationship between social support, treatment attitudes and beliefs and self-management of
empty-nest elderly patients with hypertension, and to provide a scientific basis for improving their self-management level. Methods:
We established the social support rating scale, the scale of attitude and belief in treating hypertension, and the self-management scale
of patients with hypertension to make a survey among 208 subjects. Results: The social support rating scale score was 41.93±5.48
points, the scale of attitude and belief in treating hypertension scored 64.22±10.92 points, and the self-management scale of patients
with hypertension scored 70.68±9.21 points. There was a positive correlation between attitude and belief in hypertension treatment and
social support and hypertension self-management（P<0.05）. Social support had a partial mediating effect between attitudes and beliefs
in the treatment of hypertension and self-management of hypertension. The 95% confidence interval of the mediating effect was
（0.160, 0.508）. The mediating effect accounted for 41.42% of the total effect. Conclusion: Social support, treatment attitudes and
beliefs are closely related to the self-management level of empty-nest elderly patients with hypertension. The self-management level
can be improved by promoting social support and treatment attitudes and beliefs of patients.

Application of Occupational Therapy under MOHO in the Rehabilitation of Inpatients with Serious Mental Illness

Zhao Yuping, Liu Shan, Li Yan

2021, 6(4): 85-87.

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〔Abstract〕Objective: To examine the effect of occupational therapy under MOHO mode for the rehabilitation of persons with severe
mental illness. Methods: 40 hospitalized patients with severe mental illness were divided into the observation group and the control
group. The control group was given routine mental care. In the observation group, MOHO-ST was used to evaluate the information of
patients′ working ability, and occupational therapy was supplemented by token economy treatment. The changes in the scores of SANS,
NOSIE-30 and ADL before and after treatment were compared between the two groups. Results: After treatment, the SANS score of the
observation group decreased and the score was lower than that of the control group; ADL score of the observation group decreased, the
total positive factor score of nosie-30 was higher than that of the control group, and the total negative factor score was lower than that of
the control group. The difference was statistically significant（P < 0.05）. Conclusion: The occupational therapy under MOHO is
helpful to improve the withdrawal, isolation and laziness of patients with serious mental diseases, and promote their self-care ability.
Thus, the therapy has high clinical application value.

Analysis of the Effect of Nursing Intervention on Enhancing the Treatment Success Rate among Patients with Pulmonary Tuberculosis#br#

Zhao Guifen

2021, 6(4): 88-89.

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〔Abstract〕Objective：To examine the effect of nursing intervention on improving the success rate of treating patients with pulmonary
tuberculosis, and to provide a reference for enhancing the treatment success rate. Methods：According to when nursing intervention
was conducted, the subjects were divided into the control group and the intervention group. The treatment success rate and effects in
the two groups before and after treatment were compared. Results：The success rate of nursing intervention on treating tuberculosis
patients increased from 87.86% to 93.63%, with statistically significant differeneces（P < 0.05）. Conclusion: Nursing intervention can
significantly improve the treatment success rate among tuberculosis patients, and it is worth to be popularized.

Establishment of Pre-discharge Transitional Wards with Family Participation for Preterm Neonates in Yunnan Province and Its Effect Evaluation#br#

Yin Lijuan, Yuan Yuan, Zhang Jinqiu, Gao Jin

2021, 6(4): 90-93.

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〔Abstract〕Objective: To explore the significance and effect of the establishment of pre-discharge transitional wards with family
participation for preterm neonates in Yunnan Province. Methods: We selected 45 pairs of premature infants with similar degrees of
illness and family backgrounds, who were hospitalized in NICU of a Grade-A Children′s Hospital in Yunnan Province from January
2019 to January 2020. Preterm neonates in the control group were treated in NICU until discharged from hospital, while preterm
neonates in the experimental group were treated on the transitional ward with parents participating in nursing care before discharge. We
compared parents′ abilities to care for preterm neonates outside of the hospital and the life quality of neonates after discharge between
the two groups. Results: The care ability of caregivers in the experimental group was significantly higher than that in the control group,
and the visit rate of non-primary diseases in the experimental group was lower than that in the control group within 1 month after
discharge, and the difference was statistically significant（P<0.05）. There were no nosocomial infections both in the experimental and
control groups. Conclusion: The establishment of transitional wards with the family participating in nursing care for premature infants
can enhance the care ability of caregivers and improve the life quality of premature infants after discharge. This is a care strategy which
should be recommended under the current medical system.

Effect of the Application of Clinical Nursing Pathway in Kids with Diarrhea

Yang Hongping, Liu Li, Qu Yan, Zhou Juhong, Bai Yakun, Zhuang Lijuan

2021, 6(4): 94-96.

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〔Abstract〕Objective: To examine the values of clinical nursing pathway in the treatment of kids with infantile diarrhea. Methods:
We selected 192 children with diarrhea from October 2017 to September 2019 in Pediatrics of Luliang County People′s Hospital. They
were divided into the observation and control groups with 96 cases in each group by random number table. Patients in the control group
underwent routine nursing mode, while clinical nursing pathway model based on the routine nursing care was applied to the observation
group. Results: The observation group was better than the control group in the frequency of diarrhea, the length of hospital stay,
hospitalization expenses, the nursing effect and the satisfaction of parents. The differences between the observation group and the
control group were statistically significant（P < 0.05）. Conclusion: The application of clinical nursing pathway in children with
diarrhea significantly improves the clinical effects, and has a greater clinical application value.

A Survey of the Completion Competence of Nursing Students in Higher Vocational Colleges and Its Training Strategies#br#

Zhuang Lijuan, Ma Yunchun, Yan Xue, Yang Hongping

2021, 6(4): 97-100.

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〔Abstract〕Objective: To investigate the status quo of the completion competence of nursing students in higher vocational colleges,
offer some strategies to improve their completion competence by identifying the areas that need to be further developed, and provide a
basis and reference for enhancing nursing students′ completion competence in higher vocational colleges. Methods: The Chinese
version of the Nursing Students Competence Instrument was used to survey and identity the competence of 653 nursing students in a
vocational college. Results: The total score of the completion competence of nursing students in the college was 143.18±49.33, the
average score of the items in the dimension of integrated nursing competency was the lowest, and the average score of the items in the
dimension of dealing with pressure was the highest. Juniors of the 3-year degree had higher competence than sophomores, and
sophomores had higher competence than freshmen, with the statistically significant difference（P＜0.001）. The competence of the fifth-
year nursing students of 5-year junior college education was higher than that of the fourth-year students, with the statistically
significant difference（P＜0.001）. Conclusion: The competence of nursing students in higher vocational colleges needs to be further
developed. Active study and training can positively promote their competence. Higher vocational colleges and teaching hospitals may
help nursing students develop their competence by taking such measure as reforming the teaching mode, creating a good learning
environment, establishing social support system and strengthen students′ psychological health.

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