Effects of SGLT2i on Bone Metabolism in Nephrotic Syndrome Model Rats

Abstract

Abstract:

〔Abstract〕 Objective： To study the effect of sodium glucose cotransporter 2 inhibitor（SGLT2i） canagliflozin on bone metabolism in rats with nephrotic syndrome（NS）. Methods： There were 42 male SD rats in total， among which 6 rats were randomly selected as NG group， and the other 36 rats were injected with adriamycin through tail vein for modeling and were randomly divided into 6 groups， i.e.， MG group（model group）， PG group（prednisone group）， LCG group（low-dose canagliflozin group）， HCG group（high-dose canagliflozin group）， LPCG group（low-dose canagliflozin+prednisone group） and HPCG group（high-dose canagliflozin+prednisone group）， with 6 rats in each group. The rats were treated by regular gavage every morning for 6 weeks. At the end of treatment， 24 h-UTP， urinary calcium， urinary phosphorus， serum albumin（ALB）， blood calcium， blood phosphorus， alkaline phosphatase（ALP） and bone mineral density were measured. Results： Compared with NG group， ALP level increased in MG， PG， HCG and HPCG groups， and pelvic bone mineral density decreased in all drug treatment groups， PG and HPCG group caused the decrease of systemic bone mineral content， trunk and rib bone mineral density. Compared with MG group， 24h-UTP level decreased and ALB level increased in all drug treatment groups.Urinary calcium level increased in LPCG and HPCG groups. Serum phosphorus level increased in PG group. Conclusion：canagliflozin can effectively reduce urinary protein and increase ALB. So it can be used in the treatment of NS， but it can cause the decrease of pelvic bone mineral density. High-dose canagliflozin or its combination with prednisone can also cause abnormal calcium and phosphorus metabolism， increase ALP， expand the range of bone mineral density decline， and increase the risk of osteoporosis.

Key words:

"> ">〔Key words">〕 sodium glucose cotransporter 2 inhibitor">； bone mineral density">； calcium and phosphorus metabolism">； nephrotic syndrome

CLC Number:

Hong Wenjuan, Zou Jiulin, Yu Zhuorui, Cheng Jiamao, He Minhua.

Effects of SGLT2i on Bone Metabolism in Nephrotic Syndrome Model Rats [J]. Journal of Dali University, 2022, 7(4): 21-25.

References

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