Journal of Dali University ›› 2022, Vol. 7 ›› Issue (8): 28-32.

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Expression and Clinical Significance of TTF-1 in Endometrial Carcinoma

Xu Chunhong1Dai Baoxiu2 Pan Yun3   

  1. 1.Dali Nursing Vocational College Dali Yunnan 671006 China 2.People's Hospital of Yuxi Yuxi Yunnan 653100 China 3. The First Affiliated Hospital of Dali University Dali Yunnan 671000 China

  • Received:2021-06-07 Revised:2021-07-27 Online:2022-08-15 Published:2022-09-16

Abstract: Objective: To detect the expression of thyroid transcription factor-1(TTF-1) in normal endometrium, endometrial hyperplasia and endometrial carcinoma,and analyze the relationship between the TTF-1 expression and the clinical manifestation of carcinoma. Methods: The expression of TTF-1 was detected by immunohistochemistry in 11 specimens of regular endometrium, 17 specimens of endometrial hyperplasia, and 45 cases of endometrial carcinoma, and statistical analysis was performed combined with clinical data. Results:The positive rates of TTF-1 in normal endometrium, endometrial hyperplasia and endometrial carcinoma were 45%, 35% and 16%, respectively. Compared with normal endometrium, the positive rate of TTF-1 in endometrial carcinoma was lower, and the difference was statistically significant(P<0.05).There was no significant difference in the expression of TTF-1 between type Ⅰ and type Ⅱ endometrial carcinoma. Compared with highly-differentiated endometrial carcinoma, TTF-1 expression was significantly up-regulated in moderately- and poorly- differentiated endometrial carcinoma(P<0.05). The expression of TTF-1 in endometrial carcinoma was not correlated with the patient's nationality, age, clinicopathologic stage, depth of tumor invasion, and metastasis. Conclusion: TTF-1 may be involved in the occurrence and development of some endometrial carcinoma.

Key words: thyroid transcription factor-1, immunohistochemistry, endometrial carcinoma

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