Abstract:

Objective: To observe the toxicological safety on functional food of Tangzhikang tablets. Methods: The SD ablactated rats were randomly divided into four groups. The control group was fed with basic diet. Three experimental groups were fed with basic diet mixed with Tangzhikang tablets with the dose of 1 875, 3 750 and 7 500 mg/kg on body weight for 30 days, respectively. The corresponding indexes of each group were measured. Results: During and at the end of the experiment, the body weight, food utilization rate, full blood count, blood biochemistry, and organ/body weigh ratios had no significant differences among the four groups.Furthermore, the histopathological examination showed that there were no significant changes in liver, kidney, stomach, intestines,spleen, testicle and ovary among the 4 groups. Conclusion: Tangzhikang tablet has no acute toxic effect and is a safe functional food on rats' growth, development, metabolism and viscera organs.

Key words: Tangzhikang tablets, toxicological safety assessment, rat, 30-day feeding study