Abstract:

Objective: To explore laboratory inductive effects of the commonly used clinical antibiotics on the common pathogenic Lform
bacteria and to provide a scientific basis for clinical diagnosis and treatment. Methods: With the paper dispersion method and
tube dilution method, Staphylococcus aureus, Pseudomonas aeruginosa, E. coli and Shigella were induced by antibiotics in the
laboratory. Results: Cefazolin, cefoperazone, ampicillin, piperacillin and levofloxacin could induce Pseudominas aeruginosa, E. coli
and Shigella to some degree to form corresponding L-form bacteria. L-form Staphylococcus aureus under the same condition wasn't
induced. Conclusion: Some antibiotics under certain conditions could make some bacteria lose cell walls and become L- form
bacteria, and then change their biological characteristics, which the clinical diagnosis and treatment should attach importance to.

Key words: antibiotics, L-form bacteria, the laboratory induction