Abstract: Tazhong 16 of Tarim oil field as an example, a development method for the layer reservoir of mid-low permeability bottom water was introduced in the paper. In the early development phase,the methodology that horizontal wells being the majority compensated by vertical wells at the structural axis was adopted by comparing horizontal well productivity with that of vertical wells.With volumetric balance and reservoir simulation to analyze stratified bottom water volume，the result indicated that the water volume is large enough. When horizontal wells contain water, the water cut growth is under firm control by using persistent choke. Driving energy was evaluated by calculating the average formation pressure loss of 1%OOIP, According to major development index, the plot of water cut versus OOIP recovery, water
drive characteristic profile and water cut versus water cut growth profile, Tazhong 16 development efficiency was proved to be excellent.All these indicated that Tazhong 16 mode is one of the most successful mid-low porous stratified bottom water reservoir development paradigms.

Key words: layered pool, mid-low permeability, edge-water reservoir, horizontal well