Abstract: 〔Abstract〕Objective: To explore the anti- diabetic molecular mechanism of Polygonati Rhizoma by network pharmacology.
Methods: The active components of Polygonati Rhizoma were obtained from TCMSP database. The target of Polygonati Rhizoma was
screened by HIT and TTD databases; target dataset was established; OMIM database was used to screen the diabetes-related targets,
and PPI database was used to construct the interactive targets for Polygonati Rhizoma and diabetes. Cytoscape software was used to
construct a "component-target-disease" interactive network map, and the target function and signaling pathway were analyzed by the
GO and KEGG pathways in the DAVID database. Results: The 12 active components of Polygonati Rhizoma were screened, and the
active components of Polygonati Rhizoma were involved in 17 targets including insulin receptor, Caspase-3, inducible nitric oxide
synthase and estrogen receptor, etc. Anti- diabetic effects of Polygonati Rhizoma was regulated by multiple signaling pathways
including PI3K-Akt signaling pathway, AMPK signaling pathway, Insulin resistance, Insulin signaling pathway and Type II diabetes
mellitus. Conclusion: This study demonstrates the multi-component-multi-target-multi-pathway characteristics of Polygonati Rhizoma,
which provides a new idea and scientific basis for further research on the molecular mechanism of anti-diabetic effect of Polygonati
Rhizoma.

Key words: 〔Key words〕Polygonati Rhizoma, diabetes, network pharmacology, Insulin receptor