Establishment and Evaluation of Clinical Prognostic Model of Hepatocellular Carcinoma Based on Pyroptosis-Related Genes

Abstract

Abstract:

〔Abstract〕 Objective： To explore the pyroptosis-related genes（PRGs） that are closely related to the prognosis of hepatocellular carcinoma（HCC）， and construct a corresponding prognostic risk model to evaluate the survival and prognosis of HCC patients. Methods： The transcriptome data and clinical data of HCC were downloaded from TCGA database， and the differentially expressed PRGs were screened out. COX analysis was used to determine the PRGs related to the prognosis of HCC and construct a prognostic risk score model， while K-M survival curve， receiver operator characteristic curve（ROC curve） and nomogram were plotted to analyze and verify the accuracy of the model and its prognostic value. Results： 58 differentially expressed PRGs were screened. GO function enrichment analysis showed that these genes were involved in pyroptosis， and KEGG signal pathway analysis showed that these genes were mainly enriched in non-alcohdic fatty liver disease and Toll-like receptor signal pathways. Eight PRGs significantly related to the prognosis of HCC were identified by COX analysis， and a prognostic risk score model was constructed. ROC curve showed that the area under the curve value of this risk score was 0.802， which was higher than other clinical data and could be as an independent prognostic factor. Conclusion： The prognostic risk model constructed by 8 PRGs can effectively predict the prognosis of patients with HCC.

Key words:

"> font-size:10.5pt, ">hepatocellular carcinoma, pyroptosis-related genes, prognostic model, TCGA database, bioinformaticsfont-size:10.5pt, ">

CLC Number:

Liu Chuanming, Li Xie, Lu Xikui, Zeng Diandian, Chen Jie.

Establishment and Evaluation of Clinical Prognostic Model of Hepatocellular Carcinoma Based on Pyroptosis-Related Genes [J]. Journal of Dali University, 2022, 7(10): 52-59.

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