Analysis of the Diagnostic Value of Combined Detection of MIP-1β、IL-27 and IL-35 in Tuberculous Pleural Effusion

Abstract

Abstract:

Objective： To explore the diagnostic value of combined detection of macrophage inflammatory protein 1β（MIP-1β）、 interleukin（IL） -27 and IL-35 in tuberculous pleural effusion（TPE）. Methods： A total of 106 patients with TPE admitted to Luojiang District People's Hospital and Medical Group Hospital in Deyang City from May 2021 to December 2022 were selected as the study subjects（research group）， and 106 patients with malignant pleural effusion （MPE） admitted at the same time were selected as the control group. The expression levels of MIP-1β， IL-27 and IL-35 in the serum of the two groups were detected by enzyme-linked immunosorbent assay. The expression levels of the three cytokines were compared before and after treatment in the research group， and receiver operating characteristic（ROC） curve was plotted to evaluate the diagnostic value of individual and combined detection of the markers. Results： Compared to the control group， the levels of serum MIP-1β and IL-35 in the research group were significantly increased， while the level of IL-27 was significantly decreased， with statistical significance（P<0.01）. Compared to before treatment， the levels of serum MIP-1β， IL-27 and IL-35 in the research group were significantly decreased after treatment， with statistical significance（P<0.01）. ROC curve analysis showed that the diagnostic efficacy of the combined detection of MIP-1β， IL-27 and IL-35 was significantly higher than that of individual markers（P<0.05）. Conclusion： MIP-1β， IL-27 and IL-35 can be used for the differential diagnosis of TPE and MPE， and the combined detection can improve the diagnostic efficiency.

Key words:

macrophage inflammatory protein 1β, interleukin-27, interleukin-35, tuberculous pleural effusion, malignant pleural effusion, combined diagnosis

CLC Number:

R521.7 ','1');return false;" target="_blank">
R521.7

Zhong Xiaoxia, Zhou Shixiong, Zhang Le, Cai Weiling.

Analysis of the Diagnostic Value of Combined Detection of MIP-1β、IL-27 and IL-35 in Tuberculous Pleural Effusion [J]. Journal of Dali University, 2023, 8(10): 72-75.

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