J4 ›› 2015, Vol. 14 ›› Issue (8): 22-24.

• 临床医学 • 上一篇    下一篇

肠道套细胞淋巴瘤6例临床分析并文献复习

  

  1. 大理学院昆明附属医院,昆明650011
  • 收稿日期:2014-09-25 出版日期:2015-08-15 发布日期:2015-08-15
  • 作者简介:朱为梅,副主任医师,主要从事消化内科及消化内镜研究.

Clinical Analysis and Literature Review of Six Cases of Intestinal Mantle Cell Lymphoma

  1. (Affiliated Hospital of Dali University in Kunming, Kunming 650011, China)
  • Received:2014-09-25 Online:2015-08-15 Published:2015-08-15

摘要:

目的:提高对肠道套细胞淋巴瘤的认识。方法:回顾性分析广州中山大学第一附属医院内镜中心2008年5月至2012年
6月经肠镜及免疫组化检查确诊为肠道套细胞淋巴瘤6例患者的临床资料,尤其是病理及肠镜表现。结果:肠道套细胞淋巴瘤
主要好发于老年男性,肠镜下肠道多呈多发性淋巴瘤样息肉改变。免疫组化显示几乎所有病例均表达T细胞相关抗原CD5,
过度表达细胞周期素D1(CyclinD1),部分可表达CD43而CD23、CD10(-)。结论:肠道套细胞淋巴瘤是一种难治性淋巴瘤,预
后较差,肠镜下获取优良的病理标本并进行免疫分型是诊断的最重要手段。

关键词: 套细胞淋巴瘤, 非霍奇金淋巴瘤, 预后

Abstract:

Objective: To improve the awareness of intestinal mantle cell lymphoma. Methods: Six clinical cases which were
identified as intestinal mantle cell lymphoma through colonoscopy and immunohistochemistry by the First Affiliated Hospital of Sun
Yat-sen University from May 2008 to June 2012 were retrospectively analyzed. Results: It is clear that a significant percentage of
intestinal mantle cell lymphoma occurs in old aged male. Multiple lymphomatous polyposis has been found in intestine under
colonoscopy. Furthermore, immunohistochemistry presents that most all cases express T-cell associated antigen CD5, and over express
cycling D1. At the same time, some cases also express CD43, while others show the negative CD23 and CD10. Conclusion: Intestinal
mantle cell lymphoma is a refractory lymphoma with limited curative effect. Biopsy specimen by colonoscopy and process
immunophenotype is an important diagnosis method.

Key words: mantle cell lymphoma, non-Hodgkin lymphoma, prognosis

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