枸橼酸咖啡因对早产儿原发性呼吸暂停的疗效分析

›› 2017, Vol. 2 ›› Issue (2): 61-63.

枸橼酸咖啡因对早产儿原发性呼吸暂停的疗效分析

（昆明医科大学第六附属医院新生儿科，云南玉溪653100）

收稿日期:2016-03-22 修回日期:2016-05-24 出版日期:2017-02-15 发布日期:2017-02-15
作者简介:杨杰，主治医师，主要从事新生儿疾病的诊治及保健研究.

Efficacy Analysis of Caffeine Citrate on Primary Apnea in Premature Infants

（Department of Neonatology, The Sixth Affiliated Hospital of Kunming Medical University, Yuxi, Yunnan 653100, China）

Received:2016-03-22 Revised:2016-05-24 Online:2017-02-15 Published:2017-02-15

摘要/Abstract

摘要：

目的：探讨枸橼酸咖啡因在早产儿原发性呼吸暂停治疗中的疗效及安全性。方法：回顾性分析2014年11月至2015年
10月收住NICU的92例27~32周呼吸暂停的早产儿临床资料，治疗组采用枸橼酸咖啡因治疗（n=52），对照组用氨茶碱治疗（n=
40），对比两组对呼吸暂停治疗的有效性，以及心动过速、高血糖、激惹、腹胀、胃潴留不良反应的发生率。结果：治疗组的临床
总有效率为90.4%，高于对照组的70.0%，两组比较差异有统计学意义（P＜0.05）。患儿在治疗期间心动过速、高血糖、激惹、腹
胀、胃潴留发生率治疗组低于对照组（P＜0.05）。结论：枸橼酸咖啡因对原发性早产儿呼吸暂停的疗效显著，降低呼吸暂停的
发生率，不良反应发生较少，改善预后。

关键词: 枸橼酸咖啡因, 早产儿, 低出生体重儿, 呼吸暂停

Abstract:

Objective: To investigate efficacy and safety of caffeine citrate for treating primary apnea in premature infants. Methods:
A retrospective analysis was conducted among clinical data of 92 cases of apnea in premature infants of 27-32 weeks in NICU during
November 2014 to October 2015. They were divided into two groups: observation group of caffeine citrate treatment（n=52）and the
control group of aminophylline treatment（n=40）. A comparison of the effectiveness of two apnea treatment and adverse reactions
incidence rate of tachycardia, hyperglycemia, irritability, bloating and gastric retention were done. Results: The clinical total effective
rate of the observation group was 90.4%, which was 70.0% higher than the control group. The difference was statistically significant
（P<0.05）. The rate of tachycardia, hyperglycemia, irritability, bloating, gastric retention during treatment of the observation group was
lower than the control group（P<0.05）. Conclusion: Caffeine citrate has significant effect on treating premature infants of primary
apnea, reducing the incidence of apnea, causing fewer adverse events and improving prognosis.

Key words: caffeine citrate, premature infants, low-birth-weight children, apnea

中图分类号:

R722.12

杨杰，杨秀玲，祁会仙，舒蕾. 枸橼酸咖啡因对早产儿原发性呼吸暂停的疗效分析[J]. , 2017, 2(2): 61-63.

Yang Jie, Yang Xiuling, Qi Huixian, Shu Lei. Efficacy Analysis of Caffeine Citrate on Primary Apnea in Premature Infants[J]. , 2017, 2(2): 61-63.

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