关键词: 右美托咪定, 肺灌洗, 血流动力学, 应激反应

Abstract: Objective: To observe the effects of dexmedetomidine on hemodynamics and stress response in patients with lung lavage.
Methods: Sixty patients who underwent lung lavage in the First Affiliated Hospital of Dali University were randomly divided into two
groups, i.e., the control group (group C) and the dexmedetomidine group (group D). Group D was intravenously infused with
dexmedetomidine before the induction of anesthesia; group C was given an equal volume of 0.9% sodium chloride solution. Before
infusion of dexmedetomidine or 0.9% sodium chloride solution (T0), immediately after tracheal intubation (T1), at the beginning of
left lung lavage (T2), at the beginning of right lung lavage (T3), and at extubation (T4), and 5 minutes after extubation (T5), the mean
arterial pressure (MAP) and heart rate (HR) of the two groups of patients were recorded, and plasma epinephrine and norepinephrine
levels were measured at each time point. Results: Compared with T0, MAP and HR were increased at T1 to T5 in group C. In group D,
MAP and HR increased significantly only at T4. Compared with group C, MAP and HR in group D were significantly lower at T1, T2,
T3 and T4 , the differences were statistically significant (P<0.05). Plasma epinephrine and norepinephrine in the two groups increased
at T1, T2, T3 and T4. However, compared with group C, the increase in the group D was significantly reduced in these time points,
the differences were statistically significant (P<0.01). Conclusion: Dexmedetomidine can inhibit hemodynamic fluctuations and stress
response in patients with lung lavage.

Key words: dexmedetomidine, lung lavage, hemodynamics, stress response