Abstract:

Objective: To optimize the best preparation technology of ChlorphenamineMaleate dropping pills. Methods: It was
studied with L₉（3⁴）orthogonal design, dissolution, integrality, subside ,hardness and weight variation was used as evaluation indicator to select good dropping conditions. Results: The optimized preparation conditions were as follows: PEG 6000 was the optimal base,the proportion of optimal drugs to the bases being 1:2; the temperature of liquid was 70°C and liquid paraffin was condensate; the internal and external diameter of burette was 2. 0 mm and 3. 0 mm respectively; the dropping speed was 60 drop/min and the temperature of refrigerant was（8±0.3）°C; the dropping distance was 6 cm. Conclusion: The preparation technology was feasible, which met the criterion of Chinese Pharmacopoeia 2005.

Key words: ChlorphenamineMaleate dropping pills, preparation technology, polyglycol, orthogonal test