Abstract:

lAbstract]Objective：To investigate the distribution and antimicrobial resistanee of sputum samples from patients with pulmonary tuberculosis combined with lower respiratory tract infection in our hospital to guide a rational use of drugs．Methods：Pathogens isolated from 1 32 1 sputum samples from patients with pulmonary tuberculosis and lower respiratmT tract infection in our hospital in the last two years were analyzed retrospectively．Results：Four hundred and eighty—nine pathogens were detected in 1 32 1 samples, including 1 84 (37．6％ )strains of gram—positive bacteiia，which were mainly Staphylococcus epidermidis，Enterococcus faecalis．Streptococcus and Staphylococcus aureus；1 69 (34．6％ )strains ofgram—negative bacteria，which were mainly Escherichia coli，calcium acetate Acinetobacter．Pseudomouas and Klebsiella；1 36 (27．8％ )strains of fungi．Ⅲost of which were Candida albicans．Drug susceptibility results(except
fungi j showed that most gram—positive and gram-negative bacteria were resistant to a variety of antibiotics．And the antibiotics with higher resis tance rates were：oxacillin，clindamycin，sulfamethoxazole，erythromycin，vaneomycin，penicillin sodium，ciprofloxacin， levofloxacin；relatively higher sensitive antibiotics were imipenem，cefepime，amikacin，tobramycin，cefotaxime sodium ，cefiriaxone
sodium，cefoperazone sodium．Conclusion：Pathogens in puhnonary tuberculosis and bacterial lower respiratory tract infection were mostly opportunistic pathogens，which were with nmhiple dru g resistance．Rational USe of antibiotics based on drug susceptibility results and clinical monitoring should be strengthened．

Key words: pulmonary tuberculosis, lower respiratory tract infelction, pathogens, antimicrobial resistance analysis