J4 ›› 2012, Vol. 11 ›› Issue (3): 18-20.

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Synthesis of 5-(2-(methoxycarbonyl)-trans-ethenyl)-7-methoxy -2-(4-benzyloxyphenyl)benzo[b]furan

Objective: To synthesize 5-（2-（methoxycarbonyl）-trans-ethenyl）-7-methoxy-2-（4-benzyloxyphenyl）benzo[b]furan through Vilsmier reaction，elimination reaction and substituted reaction.Methods: By studying the relative literatures, we found the way to synthesize 5-（2-（methoxycarbonyl）-trans -ethenyl）-7-methoxy-2-（4-benzyloxyphenyl）benzo[b]furan. Results: 5-（2-（methoxycarbonyl）-trans- ethenyl）-7-methoxy-2-（4-benzyloxyphenyl）benzo[b]furan was synthesized. Conclusion: Its yield was 25.2%, mp170-171 0C and purity 99.08%.   

  1. College of Pharmacy and Chemistry, Dali University, Dali, Yunnan 671000, China
  • Received:2011-09-29 Revised:2011-12-08 Online:2012-03-15 Published:2012-03-15

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Abstract:

Objective: To synthesize 5-（2-（methoxycarbonyl）-trans-ethenyl）-7-methoxy-2-（4-benzyloxyphenyl）benzo[b]furan through Vilsmier reaction，elimination reaction and substituted reaction.Methods: By studying the relative literatures, we found the way to synthesize 5-（2-（methoxycarbonyl）-trans -ethenyl）-7-methoxy-2-（4-benzyloxyphenyl）benzo[b]furan. Results: 5-（2-（methoxycarbonyl）-trans- ethenyl）-7-methoxy-2-（4-benzyloxyphenyl）benzo[b]furan was synthesized. Conclusion: Its yield was 25.2%, mp170-171 0C and purity 99.08%.

Key words: 4-hydroxy acetophenone, alkylatio, Vislsmeie, synthesis, 5-(2-(methoxycarbonyl)-trans-ethenyl)-7-methoxy-2-(4-
benzyloxyphenyl)benzo[b]furan

CLC Number: