Abstract:

Objective: To analyze clinical efficacy of nasal continuous positive airway pressure ventilation（CPAP）in the treatment
of preterm infants with respiratory distress syndrome（NRDS）and explore the value of CPAP for NRDS preterm infants. Methods:Based on combined therapy, CPAP was adopted for 84 cases with RDS from Oct. 2012 to Oct. 2013 at the neonatal department of the Maternal and Child Health Care Hospital of Dali Prefecture with the neonatal gestation age between 32 and 36 weeks. The efficacy was observed before the adoption of CPAP and six hours after the adoption of CPAP. Results: Six hours after the adoption of CPAP, cyanosis disappeared, inspiratory dyspnea was alleviated, the respiratory rate dropped to（58.2±4.7）/min, the heart rate dropped to （142.8±9.4）/min, fraction of inspired oxygen was（42.0±7.3）%, percutaneous oxygen saturation remained（94.8±4.5）%, the arterial
partial pressure of oxygen fell to（8.7±0.7）kPa and arterial partial pressure of carbon dioxide fell to（5.3±0.6）kPa, which showed significant difference. There was no other obvious complication except that the condition of 2 cases aggravated and therefore invasive mechanical ventilation was adopted. Conclusion: CPAP had a good curative effect on RDS preterm infants and the side effect was not serious and the earlier the treatment begun, the higher the cure rate and success rate were. Therefore, CPAP was worthy of introduction and promotion in primary hospitals.

Key words: nasal continuous positive airway pressure ventilation（CPAP）, Neonatal Respiratory Distress Syndrome（NRDS）, value