Objective: To strengthen the nursing risk management, refine the nursing system and improve nurses' consciousness of risk and prevention. Methods: A series of risk management measures were implemented, such as analyzing risk factors,strengthening the risk consciousness, carrying out the training of "professional knowledge, theories and skills", and adopting the management of "fixed nursing post, personalized nursing content and humanized whole nursing course", emphasizing "the important time period, patient, and observation" and making responsibilities, system and monitoring all in place. Results: Nurses' risk consciousness was improved remarkably. In addition, nursing quality and patients' satisfaction increased, errors and accidents decreased greatly, 26 wards passed the inspection of "High Quality Nursing Service Demonstration Project" and nursing service built up a reputation for the hospital. Conclusion: Improving the consciousness of risk prevention, establishing an effective risk management mechanism and attaching importance to detail management were three basic and critical factors.