A Study of Effects and Mechanism of Pitavastatin on Monocrotaline-induced Pulmonary
Arterial Hypertension in Rats

Abstract

Abstract:

Objective: To investigate effects and mechanism of pitavastatin on monocrotaline（MTC）- induced pulmonary artery
hypertension in rats. Methods: 50 male Sprague-Dawley rats were randomly divided into five groups: pulmonary arterial hypertension group, normal control group, pitavastatin prevention group（1 mg/（kg·d））, low-dose pitavastatin treatment group（1 mg/（kg·d））and highdose pitavastatin treatment group（3 mg/（kg · d））. Pulmonary arterial hypertension was induced by a subcutaneous injection of monocmtaline in rats of all groups except for the control group. After 8 weeks, survival rates and mean pulmonary arterial pressure（mPAP）among all groups were compared. The expression levels of platelet-derived growth factor-B（PDGF-B）and Rac1mRNA,secretion of IL-6 in small pulmonary artery were also detected. Results: All rats in the prevention group and normal control group survived and pitavastatin improved survival（P<0.01）. Pitavastatin in both prevention and treatment groups significantly lowered mPAP（P<0.05）, and also inhibited PDGF-B expressions and IL-6 secretion（P<0.05）, and inhibited Rac1mRNA expressions（P<0.05）. Conclusion: The effect of pitavastatin's reducing monocrotaline-induced pulmonary arterial hypertension in rats might result from the inhibition of expressions of PDGF-B and Rac1mRNA and inhibition of smooth muscle cell proliferation and inflammatory mediator IL-6．

Key words: pulmonary arterial hypertension, monocrotaline, pitavastatin, vascular smooth muscle

CLC Number:

R965

Zhou Shubo, Zhang Bensi. A Study of Effects and Mechanism of Pitavastatin on Monocrotaline-induced Pulmonary
Arterial Hypertension in Rats[J]. J4, 2015, 14(2): 16-20.

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