A Study of the Anti-inflammatory Effect and Mechanism of CⅡ-3 Extracted from Periplaneta americana

Abstract

Abstract:

Objective: To study the anti- inflammatory effect and mechanism of C Ⅱ- 3 extracted from Periplaneta americana.
Methods: The effect of CⅡ-3 on the acute inflammation of rat ear swelling caused by dimethylbenzene and rat toes swelling by
carrageenin was observed, and the mechanism was discussed. Results: 50, 100 mg/kg of CⅡ-3 could obviously inhibit the rat ear
swelling; 100, 200 mg/kg of CⅡ-3 could obviously inhibit the toes swelling, especially decrease the content of PGE2, histamine and
MDA, and stimulate the activity of SOD in the inflammatory tissue. Conclusion: CⅡ-3 showed a good inhibitory effect on the acute
inflammation and the mechanism may be related to the decrease of the content of inflammatory mediators and the scavenging of free radicals.

Key words: Periplaneta americana, anti-inflammation, PGE2, histamine

CLC Number:

R967

Chen Junya, Li Hongwen, Wu Daoxun, Liu Guangming, Peng Fang, Geng Ling. A Study of the Anti-inflammatory Effect and Mechanism of CⅡ-3 Extracted from Periplaneta americana[J]. J4, 2015, 14(2): 8-11.

References

〔1〕陈俊雅，耿玲，张旭强，等. 美洲大蠊提取物CⅡ-3对H22
肝癌小鼠血管生成作用的研究〔J〕. 肿瘤学杂志，2012，
18（4）：274-276.
〔2〕张小雪，李春艳，徐静，等. 美洲大蠊提取物对肝星状细
胞增殖能力的影响〔J〕. 大理学院学报，2012，11（6）：16-
19.
〔3〕甘平，张旭强，郭品，等. 美洲大蠊提取物CⅡ-3对豚鼠
离体回肠收缩活动的影响〔J〕. 大理学院学报，2010，9

（12）：20-22.
〔4〕张旭强，何旭，陈俊雅，等. 美洲大蠊提取物CⅡ-3对大
鼠急性酒精性肝损伤的保护作用〔J〕. 大理学院学报，
2011，10（12）：1-5.
〔5〕彭丽，陆丽，张旭强，等. 美洲大蠊提取物CⅡ-3对大鼠
心律失常的保护作用〔J〕. 大理学院学报，2011，10（12）：
6-9.
〔6〕陆丽，张旭强，甘平，等. 美洲大蠊提取物对ISO致大鼠心
肌缺血的保护作用〔J〕. 大理学院学报，2014，13（8）：7-10.
〔7〕魏伟，吴希美，李元建. 药理实验方法学〔M〕. 4版. 北京：
人民卫生出版社，2010：742.
〔8〕李杨，陆倩，钱金栿. 天南星提取物的抗炎作用及机制研
究〔J〕. 大理学院学报，2013，12（9）:14-16.
〔9〕薛原. 牛磺胆酸的抗炎作用及其作用机理的研究〔D〕. 呼
和浩特：内蒙古农业大学，2005.
〔10〕宋丹，付伟，阮金兰，等. 中日金星蕨的抗炎作用及其机
制〔J〕. 中国医院药学杂志，2011，31（8）：673-676.
〔11〕张黎，陈志武，王瑜，等. 银杏叶总黄酮抗炎作用及机制
的探讨〔J〕. 安微医科大学学报，2001，36（5）：350-352.
〔12〕李恒华，陈国庆，张毅，等. 四乙酰葛根素抗炎作用及机
制研究〔J〕. 中国实验方剂学杂志，2012，18（13）：177-
180.
〔13〕陶勇，肖玉秀，石米扬，等. 连钱草提取物对炎症递质的
影响〔J〕. 医学导报，2007，26（8）：840-843.
〔14〕李霞，于庆海，艾朋，等. 人工培植牛黄抗炎作用及其机
制的初步探讨〔J〕. 沈阳药科大学学报，2000，17（6）：
431-433.
〔15〕赵文静，蒋蕾，旺建伟. 羊胆汁抗急性炎症作用于PGE2
含量变化相关的实验研究〔J〕. 中医药信息，2009，26
（5）：50-52.
〔16〕马清钩，王淑玲. 常用中药现代研究与临床〔M〕. 天津：
天津科技翻译出版公司，1995：15-16.
〔17〕李宇馨，李瑞海. 苍术挥发油抗炎活性研究〔J〕. 辽宁中
医药大学学报，2013，15（2）：71-72.

[1]	Yang Yongshou,He Zhengchun,Xiao Peiyun. Effects of Periplaneta americana Extract on Pulmonary Fibrosis Induced by Bleomycin in Rats [J]. Journal of Dali University, 2020, 5(8): 31-37.
[2]	ChengYun,Wei Zhixin,Zhang Qian,Zou Yufeng,Yang Qian,Shao Weizai,Yang Yimei. Observation and Analysis of the Effects of Periplaneta americana Extract on Human Demodex [J]. Journal of Dali University, 2020, 5(8): 38-42.
[3]	Cui Xueping,Li Guike,Zhao Jianting,Jin Fanmao,Liu Heng,Wang Bin . Study on the Anti-inflammatory and Anti-itch Effects of Meilianjing Gel [J]. Journal of Dali University, 2020, 5(2): 38-42.
[4]	LIU Xi- , YANG Yong-Shou- , HE Zheng-Chun- , XIAO Pei-Yun. Extraction Technology of the Anti-pulmonary Fibrosis Active Site from Periplaneta americana Optimized by Orthogonal Experiment [J]. , 2019, 4(4): 1-6.
[5]	Zhou Jiaojiao, Zhang Chenggui, Liu Yuyu, Li Ruoshi, Liu Guangming, Xia Conglong. UPLC Fingerprints of Periplaneta americana Extract CⅡ-3 [J]. Journal of Dali University, 2019, 4(2): 27-.
[6]	Zhao Yanwen, Fu Wenpeng, Xie Jingjing, Yang Yongshou, Xiao Peiyun. Dual-index Sequential Analysis of Common and Variant Peak Ratio in Infrared Fingerprint of Periplaneta#br# americana [J]. Journal of Dali University, 2019, 4(12): 44-51.
[7]	Guo Chao, Lai Yong. Study on Periplaneta americana Extract on Mice Immune Function and Anti-fatigue Effects [J]. , 2018, 3(2): 10-13.
[8]	Wu Daoxun, Shao Weili, Chang Xu, Ou Hongli, Zhang Handan, Chen Junya. The Effects of Periplaneta americana Extract on Spleen Lymphocytes of H22 Tumor-bearing Mice [J]. , 2017, 2(8): 1-5.
[9]	Li Ting, Qiao Tingting, Liu Junyong, Shen Qi, Peng Fang. Research of Extracts from Periplaneta americana on Reversing Multi-drug Resistance to Bel-7402/5-Fu [J]. , 2017, 2(2): 1-5.
[10]	Man Hongxia, Na Kaige, Tan Qiaoyun, Xiao Peiyun, Yang Yongshou. Study on Extraction Process of Periplaneta americana oil [J]. J4, 2016, 1(8): 11-14.
[11]	Zhang Chunmei, Tang Xiaguang, Liu Jia, Yang Yongshou. Determination of the Content of Heavy Metal in Periplaneta americana from Different Habitats by Means of Atomic Fluorescence Spectrophotometry [J]. J4, 2016, 1(6): 43-46.
[12]	Tan Qiaoyun, Yang Yongshou, Li Kaifeng, Xiao Peiyun. Analysis of 16 Kinds of Element in the Periplaneta Americana Ootheca [J]. J4, 2016, 1(4): 22-25.
[13]	Niu Chunli, Zeng Jing, Xia Mengkai, Peng Fang. Effects of Ganlong Capsule and Periplaneta americana Skim Cream on Acute Colitis in Mice [J]. J4, 2015, 14(4): 12-16.
[14]	Xia Mengkai, Zeng Jing, Niu Chunli, Peng Fang. Effect of Ganlong Capsule and Periplaneta americana Skimmed Cream on Bile Secretion of Normal Rats [J]. J4, 2015, 14(2): 4-7.
[15]	Li Jiao, Zhang Bingqing, Liu Guangming, Xia Mengkai, Zhang Xiaodong, Liu Xiaobo. Effect of Periplaneta americana de-fat Extract on Immune Function in Mice [J]. J4, 2015, 14(10): 1-5.