›› 2018, Vol. 3 ›› Issue (10): 1-6.
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〔Abstract〕Objective:To predict the mechanism of DangGuiBuXue decoction in treating anemia by using network pharmacology technique. Methods: TDT and TCMSP databases were used to screen the chemical composition of DangGuiBuXue decoction; OMIM database screened the targets of anemia; PPI database established the interaction targets between the drug and the disease. Cytoscape software was applied to construct the "compound-target-disease" complex network diagram. Targets of DangGuiBuXue decoction were selected, which played an important role in treating anemia by using the network topological parameters such as Degree, Betweenness Centrality, Closeness Centrality. In the "component-target-disease" network of DangGuiBuXue decoction, the targets which achieved the standard were enriched by the DAVID database. Results: 15 targets correlated with anemia were screened. DangGuiBuXue decoction was useful for treating anemia via regulating cell cycle arrest and eleven pathways such as Cell cycle, P53 signaling pathway, etc. Conclusion: The mechanism of DangGuiBuXue decoction in the treatment of anemia has been predicted by network pharmacology, which can provide the theoretical basis for its clinical application.
Key words: 〔Key words〕network pharmacology, DangGuiBuXue decoction, anemia, mechanism
CLC Number:
R285
Li Yang, Hao Junjie. Network Pharmacology-based Study on Mechanism of DangGuiBuXue Decoction in Treating Anemia[J]. , 2018, 3(10): 1-6.
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