›› 2018, Vol. 3 ›› Issue (10): 7-12.
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〔Abstract〕Objective:To predict the mechanism of ephedrae herba-cinnamomi ramulus herbal pair in treating hydropsy by using network pharmacology technique. Methods: TDT and TCMSP databases were used to screen the chemical composition of ephedrae herba and cinnamomi ramulus; OMIM database screened the targets of hydropsy. A "compound-target-disease" complex network diagram was constructed with Cytoscape software. In the "component-target-disease" network of ephedrae herba and cinnamomi ramulus, the gene function and KEGG path of the selected targets were analyzed. Results: 10 protein targets effective in treating hydropsy had been screened. It was found that their treating effect was achieved mainly through regulating VEGF signaling pathway and vascular endothelial cell migration. PI3K-Akt signaling pathway, TNF signaling pathway, Ras signaling pathway and MAPK signaling pathway also played significant roles. Conclusion: The mechanism of ephedrae herba and cinnamomi ramulus in the treatment of hydropsy has been predicted by network pharmacology, which can provide the theoretical basis for its clinical application.
Key words: 〔Key words〕network pharmacology, ephedrae herba-cinnamomi ramulus herbal pair, hydropsy, mechanism
CLC Number:
R285
Hao Junjie, Li Yang. A Study on Therapeutic Mechanism of Ephedrae Herba-Cinnamomi Ramulus Herbal Pair in Treating Hydropsy[J]. , 2018, 3(10): 7-12.
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〔1〕赵杰,徐文杰,方芳,等. 麻黄-甘草药对的抗炎、利尿作 用研究〔J〕. 中药药理与临床,2012,28(3):12-14. 〔2〕卫平,郑芳昊,霍慧灵,等. 不同配伍比例对麻黄-甘草药 对中麻黄类生物碱成分血浆药动学的影响〔J〕. 中国实 验方剂学杂志,2016,22(7):100-105. 〔3〕赵杰,罗佳波,方芳,等. 麻黄-甘草药对利尿作用的定量 评价〔J〕. 中药药理与临床,2012,28(2):14-15. 〔4〕HOPKINS A L. Network pharmacology:the next paradigm in,drug discovery.〔J〕. Nature Chemical Biology,2008,4 (11):682-690. 〔5〕李梢,张博. 中药网络药理学:理论、方法与应用(英 文)〔J〕. 中国天然药物,2013,11(2):110-120. 〔6〕王涛,邹文俊,张璐,等. 基于网络药理学预测四逆汤抗 心力衰竭的作用机制〔J〕. 中国医院用药评价与分析, 2017,17(10):1304-1306. 〔7〕范文涛,王倩. 基于网络药理学的石菖蒲-郁金药对治疗 抑郁症作用机制研究〔J〕. 中国中药杂志,2018,43(12): 2607-2611. 〔8〕郝俊杰,王涛. 基于网络药理学的桂枝甘草汤治疗心律失 常的作用机制研究〔J〕. 大理大学学报,2017,2(10):1-4. 〔9〕毛定安,杨于嘉,俞燕. 热休克蛋白70对感染性脑水肿 核转录因子-κB及其抑制蛋白的影响〔J〕. 中国危重病 急救医学,2005(11):10-12. 〔10〕辛红伟,李华强,吴学建,等. 兔皮瓣移植术后血管内皮 生长因子表达与水肿关系研究〔J〕. 中华实用诊断与治 疗杂志,2013,27(6):562-564. 〔11〕宋明亮,李瑞生,高波. 可逆性后部脑病综合征细胞毒 性水肿与血清白蛋白的关系〔J〕. 医学影像学杂志,2018,28(7):1061-1064. 〔12〕张丽,陈海平. 过氧化物酶体增生物激活受体γ激动剂 致水肿机制及预防的研究进展〔J〕. 药物不良反应杂 志,2008(5):305-311. 〔13〕陈东,熊文德,胡艳萍,等. 大鼠脑损伤后脑组织肿瘤坏 死因子α、内源性一氧化氮、前列腺素E_2变化及与脑 水肿的关系〔J〕. 中国临床康复,2004(16):3054-3055. 〔14〕吴翩. 血管内皮细胞生长因子密度梯度对内皮细胞迁 移行为的调控〔D〕. 重庆:重庆大学,2015. 〔15〕索燕,刘堃,许迅. 糖尿病黄斑水肿抗血管内皮生长因 子治疗进展〔J〕. 上海交通大学学报(医学版),2012,32 (2):226-230. 〔16〕吴涛. 电针基于PI3K/AKT信号通路调控颅脑损伤大鼠 脑神经细胞凋亡及水肿机制研究〔D〕. 成都:成都中医 药大学,2017. 〔17〕张新宇,孙晓川. 肿瘤坏死因子 α 诱发脑水肿的机 制〔J〕. 重庆医科大学学报,2008(4):432-436. 〔18〕宋飞飞. 血管紧张素Ⅱ系统在家兔神经源性肺水肿中 作用的实验研究〔D〕. 上海:复旦大学,2012. 〔19〕俞华芳,樊晓明,蒋淼,等. P38MAPK抑制剂对小鼠急 性水肿型胰腺炎的作用〔J〕. 中国临床医学,2008(1): 82-83.