Yang Qiaoling, Zhao Ruodan, Liu Xiaobo, Guo Meixian, Chen Xubing. Inhibitory Effects of Vespa velutina Extract on HepG2 Human Hepatoma Cells[J]. Journal of Dali University, 2021, 6(2): 34-38.
〔1〕张延智,吴金洪,缪菊连,等. 黄脚胡蜂脂溶性成分的
GC-MS分析〔J〕. 中国民族民间医药,2020,29(2):19-21.
〔2〕李时珍. 本草纲目〔M〕. 重庆:重庆大学出版社,1994.
〔3〕邱德文,吴家荣,夏同珩. 本草纲目彩色药图〔M〕. 贵阳:
贵州科技出版社,1998.
〔4〕WANG C,CHEN T,ZHANG N,et al. Melittin,a Major
Component of Bee Venom,Sensitizes Human Hepatocellu⁃
lar Carcinoma Cells to Tumor Necrosis Factor-Related
Apoptosis-Inducing Ligand(TRAIL)-Induced Apoptosis
by Activating CaMKII-TAK1-JNK/p38 and Inhibiting
IκBα Kinase-NFκB〔J〕. J Biol Chem,2009,284(6):3804-
3813.
〔5〕宋长城,吕祥,程彬彬,等. 蜂毒素对人肝癌裸鼠移植瘤
的抗血管生成作用〔J〕. 实用癌症杂志,2011,26(6):
551-554.
〔6〕沈文文,赵斌,黄成,等. 蜂毒素对人肝癌HepG2细胞增
殖和凋亡的影响及其部分机制研究〔J〕. 中国药理学通
报,2015,31(9):1222-1227.
〔7〕柯梦云,董健,吴荣谦,等. 蜂毒肽突变体Melittin-K1抑
制人肝癌细胞BEL-7402 生长的作用〔J〕. 现代肿瘤医
学,2019,27(15):2636-2641.
〔8〕姚增胜,吴国泰. 对肝癌蜂疗一例的回忆与思考〔J〕.
蜜蜂杂志,2019,39(6):35-36.
〔9〕LI F,AWALE S,TEZUKA Y,et al. Cytotoxicity of Constitu⁃
ents from Mexican Propolis against a Panel of Six Different
Cancer Cell Lines〔J〕. Nat Prod Commun,2010,5(10):
1601-1606.
〔10〕李赫宇,赵玲. 巴西蜂胶对HepG2细胞增殖抑制活性研
究〔J〕. 食品研究与开发,2016,37(16):26-28.
〔11〕王紫燕,王莹莹,曾晓雄,等. 蜂胶中CAPE 对HGF 诱
导的HepG2 细胞侵袭和迁移能力的抑制作用〔J〕. 食
品科学,2017,38(1):203-209.
〔12〕SHERIF M S,REHAB T A,HAMDIA Z A,et al. Cytotox⁃
icity of Propolis Nanopreparations in Cancer Cell Monolay⁃
ers:Multimode of Action Including Apoptotsis and Nitric
Oxide Production〔J〕. Gen Physiol Biophys,2018,37(1):
101-110.
〔13〕ESPÍNDOLA K M M,FERREIRA R G,NARVAEZ L E
M,et al. Chemical and Pharmacological Aspects of Caffeic
Acid and Its Activity in Hepatocarcinoma〔J〕. Front Oncol,
2019,9:541.
〔14〕程林兵,龚雁,王金胜,等. 蜂毒制剂“神蜂精”对佐剂
性关节炎大鼠血管表皮生长因子及其受体的影响〔J〕.
中国蜂业,2015,66(8):47-50.
〔15〕KWON Y B,LEE H J,HAN H J,et al. The Water-Soluble
Fraction of Bee Venom Produces Antinociceptive and Anti-
Inflammatory Effects on Rheumatoid Arthritis in Rats〔J〕.
Life Sci,2002,71(2):191-204.
〔16〕谭宁,王科澎,贺守第,等. 蜂毒注射液对类风湿关节炎
成纤维样滑膜细胞凋亡影响的研究〔J〕. 新中医,2015,
47(6):280-283.
〔17〕袁恺. 蜂针对原发性肝癌患者镇痛作用的临床观
察〔D〕. 广州:广州中医药大学,2013.
〔18〕HU H,CHEN D,LI Y,et al. Effect of Polypeptides in Bee
Venom on Growth Inhibition and Apoptosis Induction of
the Human Hepatoma Cell Line SMMC-7721 in-vitro and
Balb/c Nude Mice in-vivo〔J〕. J Pharm Pharmacol,2006,
58(1):83-89.
〔19〕CHO H J,JEONG Y J,PARK K K,et al. Bee Venom Sup⁃
presses PMA-Mediated MMP-9 Gene Activation via JNK/
p38 and NF- κB-Dependent Mechanisms〔J〕. J Ethno⁃
pharmacol,2010,127(3):662-668.
〔20〕PARK J H,JEONG Y J,PARK K K,et al. Melittin Sup⁃
presses PMA-Induced Tumor Cell Invasion by Inhibiting
NF- κB and AP-1-Dependent MMP-9 Expression〔J〕.
Mol Cells,2010,29(2):209-215.
〔21〕NAM S,KO E,PARK S K,et al. Bee Venom Modulates
Murine Th1/Th2 Lineage Development〔J〕. Int Immuno⁃
phannaeol,2005,5(9):1406-1414.