Effects of Dendrobium devonianum Water
Extract on Cyclophosphamide Immunosuppressive Model Mice

Abstract

Abstract:

Objective： To investigate the effects of Dendrobium devonianum water extract（ＤＤＷＥ） on immunosuppressive model mice induced by cyclophosphamide （CTX）. Methods： CTX immunosuppressive model mice were randomly divided into groups. After 30 days of continuous intragastric administration， the phagocytic function of mice peritoneal macrophages， the proliferation ability of mice splenic lymphocytes， splenic index， T lymphocyte subsets， and the number of peripheral blood cells were measured； the level serum of immunoglobulin G（IgG）， immunoglobulin A（IgA）， immunoglobulin M（IgM）， tumor necrosis factor-α（TNF-α） and interleukin-2（IL-2） were detected by ELISA method. Results： Compared with the model group， each dosage group of DDWE enhanced the phagocytic activity of macrophages and proliferation ability of lymphocytes to varying degrees. And a dose-dependent manner increased the splenic index， the number of white blood cells， the level of CD4⁺/CD8⁺， and the levels of serum of IgG， IgA， IgM， TNF-α， and IL-2. Conclusion： DDWE strengthened the immune function of CTX immunosuppressive mice by improving the activity of immune cells and promoting the production and release of immune cytokines.

Key words:

Dendrobium devonianum">； water extract">； cyclophosphamide">； immunosuppression

CLC Number:

Zhou Tao, Huang Hangxing, Zhao Yingying, Ai Xin, Miao Zhimin, Lai Yong.

Effects of Dendrobium devonianum Water Extract on Cyclophosphamide Immunosuppressive Model Mice [J]. Journal of Dali University, 2022, 7(2): 16-21.

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Effects of Dendrobium devonianum Water Extract on Cyclophosphamide Immunosuppressive Model Mice

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