Expression and Clinical Significance of
PARVG Gene in Patients with Renal Clear Cell Carcinoma

Abstract

Abstract: Objective： To investigate the expression and function of PARVG gene in kidney renal clear cell carcinoma （KIRC） based on bioinformatics. Methods： A variety of online databases and software were used to synthetically analyze the prognostic value of PARVG gene in KIRC and its related regulatory mechanism. Results： The expression level of PARVG gene in KIRC was significantly higher than that in normal tissues adjacent to cancer （P<0.05）， and the expression level of PARVG gene was directly related to the clinicopathological features of patients with different tumor stages， grades， ethnicities and ages， and its high expression level suggested a poor prognosis （P<0.05）. There are 17 co-expressed genes of PARVG gene， and its bioinformatics function is mainly concentrated on the formation and maintenance of plasma membrane， cell communication， signal transduction and so on. Conclusion： PARVG gene is highly expressed in KIRC patients， which can be used as a potential target for diagnosis， treatment and prognosis of KIRC patients.

Key words:

, KIRC">； PARVG">； bioinformatics analysis

CLC Number:

Wang Litao, Bai Li.

Expression and Clinical Significance of PARVG Gene in Patients with Renal Clear Cell Carcinoma [J]. Journal of Dali University, 2022, 7(2): 39-45.

References

〔1〕 LJUNGBERG B， BENSALAH K， CANFIELD S， et al. EAU Guidelines on Renal Cell Carcinoma： 2014 Update〔J〕. Eur Urol， 2015， 67（5）： 913-924.

〔2〕 DELEUZE A， SAOUT J， DUGAY F， et al. Immunothe-rapy in Renal Cell Carcinoma： The Future Ｉs Ｎow〔J〕. Int J Mol Sci， 2020， 21（7）： 2532.

〔3〕 SIEGEL R L， MILLER K D， FUCHS H E， et al. Cancer Statistics， 2021〔J〕. CA Cancer J Clin， 2021， 71（1）： 7-33.

〔4〕 MILLER K D， FIDLER-BENAOUDIA M， KEEGAN T H， et al. Cancer Statistics for Adolescents and Young Adults， 2020〔J〕. CA Cancer J Clin， 2020， 70（6）： 443-459.

〔5〕 WANG X， LOPEZ R， LUCHTEL R A， et al. Immune Evasion in Renal Cell Carcinoma： Biology， Clinical Translation， Future Directions〔J〕. Kidney Int， 2021， 99（1）： 75-85.

〔6〕 CHOWDHURY N， DRAKE C G. Kidney Cancer： An Overview of Current Therapeutic Approaches〔J〕. Urol Clin North Am，2020， 47（4）： 419-431.

〔7〕 DANGER R， THERVET E， GRISONI M L， et al. PARVG Gene Polymorphism and Operational Renal Allograft Tolerance〔J〕. Transplant Proc， 2012，44（9）：2845-

2848.

〔8〕 KORENBAUM E， OLSKI T M， NOEGEL A A. Genomic Organization and Expression Profile of the Parvin Family of Focal Adhesion Proteins in Mice and Humans〔J〕. Gene， 2001， 279（1）： 69-79.

〔9〕 CASTELLV?魱-BEL S， CASTELLS A， JOHNSTONE C N， et al. Evaluation of PARVG Located on 22q13 as a Candidate Tumor Suppressor Gene for Colorectal and Breast Cancer〔J〕. Cancer Genet Cytogenet， 2003， 144（1）： 80-82.

〔10〕 LIU J H， JI C J， WANG Y C， et al. Identification of Methylation-Ｄriven Genes Prognosis Signature and Im-mune Microenvironment in Uterus Corpus Endometrial Cancer〔J〕. Cancer Cell Int， 2021， 21（1）： 365.

〔11〕 LI T， FAN J， WANG B， et al. TIMER： A Web Server for Comprehensive Analysis of Tumor-Infiltrating Immune Cells〔J〕. Cancer Res， 2017， 77（21）： e108-e110.

〔12〕 TANG Z， LI C， KANG B， et al. GEPIA： A Web Server for Cancer and Normal Gene Expression Profiling and Interactive Analyses〔J〕. Nucleic Acids Res，2017，45（W1）： W98-W102.

〔13〕 CHANDRASHEKAR D S， BASHEL B， BALASUBR-AMANYA S， et al. UALCAN： A Portal for Facilitating Tumor Subgroup Gene Expression and Survival Analy-ses〔J〕. Neoplasia， 2017，19（8）：649-658.

〔13〕 CHANDRASHEKAR D S， BASHEL B， BALASUBRAM

ANYA S A H， et al. UALCAN： A Portal for Facilitating Tumor Subgroup Gene Expression and Survival Analy-ses〔J〕. Neoplasia， 2017， 19（8）： 649-658.

〔14〕 DABESTANI S， THORSTENSON A， LINDBLAD P， et al. Renal Cell Carcinoma Recurrences and Metastases in Primary Non-Metastatic Patients： A Population-Based Study〔J〕. World J Urol， 2016， 34（8）： 1081-1086.

〔15〕 ALONSO M E， BELLO M J， DE CAMPOS J M， et al. No Evidence of INI1hSNF5（SMARCB1） and PARVG Point Mutations in Oligodendroglial Neoplasms〔J〕. Cancer Genet Cytogenet， 2005， 160（2）： 169-173.

[1]	Chen Yanan, Shi Shaomin, Fu Zi, Liu Hanfu, Jiang Bei, Shen Lei. Study on Acute Toxicity of the Bai Medicinal Plant Bauhinia brachycarpa on Mice [J]. Journal of Dali University, 2022, 7(2): 6-9.
[2]	Zhou Tao, Huang Hangxing, Zhao Yingying, Ai Xin, Miao Zhimin, Lai Yong. Effects of Dendrobium devonianum Water Extract on Cyclophosphamide Immunosuppressive Model Mice [J]. Journal of Dali University, 2022, 7(2): 16-21.
[3]	Pu Fen, Zhang Dequan. Chloroplast Genome Characteristics of a Tibetan Endangered Medicinal Plant Lamiophlomis rotata [J]. Journal of Dali University, 2022, 7(2): 22-28.
[4]	Wang Zixin, Li Xia, Zhang Hai, Qiu Lin, Lu Xiaonan, Wang Qinggui, Gu Yun. Application and Practice of Automation Construction of Pharmacy Intravenous Admixture Service [J]. Journal of Dali University, 2022, 7(2): 29-32.
[5]	Hua Hui, Xia Jing, Jia Huijie, Ge Yuchen, Wang Xiaobo . Construction of fto Knockout Mouse Model with CRISPR/Cas9 Gene Targeting Technology [J]. Journal of Dali University, 2022, 7(2): 33-38.
[6]	Liu Hongxia, Zhang Jianli, Hong Yunfei. Correlation Ａnalysis of LDL-C， CRP， BNP Levels and the Severity of Coronary Artery Disease in Patients with AMI [J]. Journal of Dali University, 2022, 7(2): 46-50.
[7]	Liu Teng, Cheng Fei, Yang Pinjiao, Jia Yunqin, Han Peiyan, Tao Tao, Duan Zhiguang. Efficacy Ａnalysis of Two Methods in the Treatment of Severe Non-Proliferative Diabetic Retinopathy [J]. Journal of Dali University, 2022, 7(2): 51-56.
[8]	Zhou Yuanyuan, Du Lingying, Qi Mengjuan, Guo Ying. Study on the Relationship between Vaginal Microenvironment， Interleukin-4 and High-Risk HPV Infection of the Cervix [J]. Journal of Dali University, 2022, 7(2): 57-61.
[9]	Fan Yujuan, Ma Yanan, Wang Li, Li Fuxing, Zhang Yulin, Cheng Mingjing, Zhao Weidong. Analysis of Clinical Distribution and Drug Resistance Trend of Klebsiella pneumoniae in Hospital A from 2018 to 2020 [J]. Journal of Dali University, 2022, 7(2): 62-66.
[10]	Cheng Mingjing, Zhang Rong, Zhang Jie, Tang Shaobo, Zhao Weidong. Analysis on Distribution Characteristics and Drug Resistance of Neisseria gonorrhoeae Infection in Hospital A from 2014 to 2020 [J]. Journal of Dali University, 2022, 7(2): 67-70.
[11]	Yin Chunlei, Liu Rongrong, Li Lijuan. Relationship between Disease Control and Intestinal Flora Structure in Patients with Schizophrenia [J]. Journal of Dali University, 2022, 7(2): 71-75.
[12]	Zhang Qian, She Rong, Yang Xiaoyan, Yin Chunlei, Li Lijuan. A Preliminary Study on the Correlation between Obesity and Oxidative Stress in College Students [J]. Journal of Dali University, 2022, 7(2): 76-81.
[13]	You Yan, Luan Yuquan, Guo Huimin, Zhang Bing, Guo Zhifang, He Qilian. Health Literacy Status and Influencing Factors of Ｅlderly People of the Bai Ethnic Group with Chronic Diseases in Yunnan Province [J]. Journal of Dali University, 2022, 7(2): 82-87.
[14]	Lu Yun, Zhang Dongjie, Shi Xinpu, Liu Yan, Li Wenming. Ｒesearch on Perceptions and Behaviors of AIDS Prevetion and Treatment among Male Homosexuals in the "Post-Epidemic Period" [J]. Journal of Dali University, 2022, 7(2): 88-93.
[15]	Shen Fang, Zhao Dongning, Tan Qiu, Fu Yanfen. Discussion on Strengthening Pre-Inspection and Triage Management Practice in COVID-19 Epidemic Prevention and Control [J]. Journal of Dali University, 2022, 7(2): 94-97.

Expression and Clinical Significance of PARVG Gene in Patients with Renal Clear Cell Carcinoma

PDF (PC)

Knowledge

Abstract

Cite this article

share this article

References

Related Articles 15

Recommended Articles

Metrics

Comments