Abstract: Objective： To investigate the current situation and trend of nosocomial infection in the Intensive Care Unit（ICU） of a tertiary hospital， to implement the infection prevention and control measures appropriately， and to further improve and strengthen the prevention and control of nosocomial infection. Methods： The study collected data of all ICU patients with nosocomial infection symptoms from 2015 to 2019 in this hospital， and statistically analyzed the prevalence of nosocomial infections in ICU and the prevalence of nosocomial infection caused by common ICU equipment. Results： From 2015 to 2019， the average nosocomial infection rate in the ICU of the hospital was 6.40%， and the average prevalence of nosocomial infections was 7.32%. The prevalence of nosocomial infection reached the highest in 2016 and the lowest in 2019. There were significant differences in the rate of ventilator-associated pneumonia and central venous catheter infection among different years（P<0.05）. The rate of catheter-related urinary tract infection was relatively stable， and there was no significant difference between different years（P>0.05）. The infection rate of ventilator-associated pneumonia（6.24‰） was higher than that of central venous catheter infection（2.00‰） and catheter-related urinary tract infection （1.04‰）. Conclusion： The infection control situation in the ICU of this hospital is generally good. With the continuous improvement of nosocomial infection prevention and control， the prevalence of nosocomial infection shows a downward trend. In the future work， the prevention and control of nosocomial infection should be further strengthened， the respiratory tract infection should be the focus of prevention and control， the principle of nosocomial infection monitoring should be implemented， in order to reduce the nosocomial infection rate.

Key words: nosocomial infection, prevalence rate, intensive care unit