Abstract:

〔Abstract〕Objective：To predict the mechanism of DangGuiBuXue decoction in treating anemia by using network pharmacology
technique. Methods: TDT and TCMSP databases were used to screen the chemical composition of DangGuiBuXue decoction; OMIM
database screened the targets of anemia; PPI database established the interaction targets between the drug and the disease. Cytoscape
software was applied to construct the "compound-target-disease" complex network diagram. Targets of DangGuiBuXue decoction were
selected, which played an important role in treating anemia by using the network topological parameters such as Degree, Betweenness
Centrality, Closeness Centrality. In the "component-target-disease" network of DangGuiBuXue decoction, the targets which achieved
the standard were enriched by the DAVID database. Results: 15 targets correlated with anemia were screened. DangGuiBuXue
decoction was useful for treating anemia via regulating cell cycle arrest and eleven pathways such as Cell cycle, P53 signaling pathway,
etc. Conclusion: The mechanism of DangGuiBuXue decoction in the treatment of anemia has been predicted by network
pharmacology, which can provide the theoretical basis for its clinical application.

Key words: 〔Key words〕network pharmacology, DangGuiBuXue decoction, anemia, mechanism