Table of Content

15 April 2024, Volume 9 Issue 4

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Construction of a Nomogram Risk Prediction Model for Treatment Outcomes of Multidrug-Resistant and Rifampicin-Resistant Tuberculosis

Li Shuolan, Wang Shuxian, Xu Yuan, Liu Cai, Li Mingwu

2024, 9(4):  1-7.  DOI: ［DOI］10. 3969 / j. issn. 2096-2266. 2024. 04. 001

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〔Abstract〕 Objective: To investigate the treatment outcomes and influencing factors of multidrug-resistant/rifampicin-resistant

tuberculosis （MDR/RR-TB）, and construct a Nomogram risk prediction model and evaluate it. Methods: Clinical data of MDR/RR

TB inpatients in Kunming Third People's Hospital from January 1 , 2019 to December 31, 2019 were collected and followed up by

telephone. χ2 test and multiple Logistic regression analysis were used to screen the influencing factors of treatment outcome

, and a Nomogram model was established for verification. Results: Among 141 MDR/RR-TB patients , 79（56.03%） were successfully treated, while 62 （43.97%） had adverse treatment outcomes. Multivariate Logistic regression analysis showed that diabetes mellitus, hematological diseases and rural residence were risk factors for treatment outcomes of MDR/RR-TB patients, while junior high school education and above was protective factor for treatment outcomes of MDR/RR-TB patients. A Nomogram model was constructed based on the above four factors. The area under the receiver operator characteristic curve was 0.752（95% CI：0.673-0.832）, with the sensitivity of 0.667 and specificity of 0.831. After 1 000 Bootstrap resamples for internal verification, the average absolute error was 0.041, and the predicted value was consistent with the actual value. The Hosmer-Lemeshow test showed that the model had a good fit（χ² =8.119，P=0.322）. The decision curve showed that the Nomogram model had certain clinical practical value in the high riskthreshold range （0.14-0.81）.Conclusion: The established Nomogram model has good predictability, consistency and clinical practicability, and can provide a scientific reference for the clinical treatment of MDR/RR-TB.

The Curriculum System Construction of "Pharmaceutical Production Quality Management Engineering" for Pharmaceutical Engineering Major Based on OBE Concept

Wen Jianxia, Liu Chuan, Deng Ke, Yang Wenyu

2024, 9(4):  8-12.  DOI: ［DOI］10. 3969 / j. issn. 2096-2266. 2024. 04. 002

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〔Abstract〕 Objective: Based on the outcome-based education （OBE） concept, the characteristic curriculum system was built through the whole-link management optimization of the teaching process of "pharmaceutical production quality management engineering". Methods: Based on the OBE concept, the curriculum system was constructed and improved from the aspects of curriculum nature, teaching objectives, curriculum content, ideological and political education and teaching methods, etc. The teaching methods had reformed, and the assessment and evaluation mechanism of the whole course process had established. Results: The curriculum system had promoted the effective connection of "industrial chain-education chain-research chain-application chain-innovation chain", and realized the deep integration of professional setting, personnel training and industrial evelopment.Conclusion: The integration of OBE concept significantly improves the teaching quality of "pharmaceutical production quality management engineering" course, which can provide reference for the construction of similar courses in other colleges and universities.

Construction and Comparison of Three Rat Models of Pulmonary Hypertension

Li Shadi, Han Yiwei, Wu Jiajia, Zhang Xiaoying

2024, 9(4):  13-18.  DOI: ［DOI］10. 3969 / j. issn. 2096-2266. 2024. 04. 003

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〔Abstract〕 Objective: To compare the characteristics of three methods: monocrotaline （MCT）, hypobaric hypoxia （HPH）, and SU5416 combined with hypobaric hypoxia （SuHx） in constructing pulmonary arterial hypertension （PH） rat models. Methods: Male SD rats were randomly divided into a control group and three experimental groups: MCT group, HPH group, and SuHx group. The MCT group received intraperitoneal injection of MCT 50 mg/kg and was routinely raised for 4 weeks. The HPH group was placed in a low pressure oxygen chamber at an altitude of 5 000 meters for 8 weeks, and the SuHx group received subcutaneous injection of SU5416 20 mg/kg and placed in a low-pressure oxygen chamber at an altitude of 5 000 meters for 3 weeks. After the model being made, the pulmonary artery pressure, right ventricular pressure, left ventricular function and blood cell count of rats in each group were measured, heart coefficient and the right heart hypertrophy index of rats were calculated

, and the pathological changes of lung tissue were observed. Results: Compared with the control group, the pulmonary artery pressure, right ventricular pressure and right ventricular hypertrophy index of the experimental group rats increased, and the right ventricular pressure of the SuHx group increased more significantly than the other two experimental groups, the difference was statistically significant（P<0.05）; The left ventricular diastolic function decreased, red blood cells and hemoglobin increased, and platelets decreased in the HPH and SuHx groups; However, in the MCT group, there was an increase in platelets, with little change in red blood cells and platelets; Compared with the control group, the pulmonary artery wall thickness of the experimental group significantly increased, the difference is statistically significant （P<0.05）. Conclusion: Three methods can be used to construct a rat model of pulmonary hypertension, and SuHx has the best modeling effect.

Reflection and Practice of Reform of the Ideological and Political Education in the Medical Microbiology Course

Wang Yu , Ao Bo , Bai Li

2024, 9(4):  19-24.  DOI: ［DOI］10. 3969 / j. issn. 2096-2266. 2024. 04. 004

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〔Abstract〕This paper analyzes the current situation and misunderstanding of ideological and political practice research of medical microbiology curriculum, carries out consistent design and practice of ideological and political practice of medical microbiology curriculum in view of existing problems, and adopts diversified evaluation methods to verify that teaching design and practice effectively realize the cultivation of students' correct world outlook, life outlook, moral outlook, rule of law outlook and ecological civilization outlook.




Correlation of ABCG2 Gene Polymorphism with Serum Uric Acid Levels in Hemodialysis Patients

Zhao Xian, Liu Liru, Yang Hua, Yang Zhengchun, Zhou Xuan

2024, 9(4):  25-31.  DOI: ［DOI］10. 3969 / j. issn. 2096-2266. 2024. 04. 005

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〔Abstract〕 Objective: To investigate the correlation between the ABCG2 functional variant Q141K （rs2231142） gene polymorphism,ABCG2 functional types, and serum uric acid （SUA） levels in hemodialysis patients. Methods: A total of 190 maintenance hemodialysis patients were selected as the study subjects. ABCG2 functional types were assessed based on the gene polymorphisms of ABCG2 functional variant Q126X （rs72552713） and Q141K. The correlation between different ABCG2 Q141K genotypes, ABCG2 functional types, and SUA levels was compared. Results: According to the ABCG2 Q141K gene polymorphism, there were 115 cases of GG genotype （60.53%）, 60 cases of GT genotype （31.58%）, and 15 cases of TT genotype（7.89%）

. According to ABCG2 functional types, there were 111 cases in the full-function group （58.42%）, 60 cases in the 3/4 function group（31.58%）, and 19 cases in the 1/2 function group （10.00%）. Differences in SUA levels among patients with different

ABCG2 Q141K genotypes and ABCG2 functional types were statistically significant（P<0.001）. Multivariate linear regression analysis showed a significant positive correlation between ABCG2 Q141K genotypes, ABCG2 functional types, and SUA levels.

Conclusion: The ABCG2 Q141K genotype and ABCG2 functional types are significantly positively correlated with SUA levels in hemodialysis patients, serving as indicators for predicting SUA levels and as therapeutic targets for reducing SUA levels in hemodialysis patients.

Efficacy and Safety Analysis of SolitAct Technique in the Treatment of Acute Large Vessel Occlusive Ischemic Stroke

Zhang Wenhao, Yang Zenghao, Zhang Rui, Duan Pengyuan, Zhang Lei, Cheng Jianjie

2024, 9(4):  32-35.  DOI: ［DOI］10. 3969 / j. issn. 2096-2266. 2024. 04. 006

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〔Abstract〕 Objective: To explore the efficacy and safety of the SolitAct technique in the treatment of acute large vessel occlusive

ischemic stroke. Methods: A retrospective analysis was conducted on the medical records of 48 patients with acute large vessel

occlusive ischemic stroke admitted to the department of neurosurgery in the First Affiliated Hospital of Dali University from May 2021 to June 2022. The analysis included the success rate of vessel recanalization, postoperative bleeding rate, and the rate of good prognosis at 3 months postoperatively. Results: The SolitAct technique achieved a vessel recanalization success rate of

87.50%, with a postoperative bleeding rate of 20.83%. The rate of good prognosis at 3 months postoperatively was 56.25%.

Conclusion: The SolitAct technique is a safe and effective endovascular recanalization method for acute large vessel occlusive ischemic stroke. It demonstrates certain advantages in achieving vessel recanalization and improving patient prognosis.




Clinical Effects of the Application of Spring Coils in the Treatment of Internal Iliac Artery During Endovascular Abdominal Aortic Repair

Liu Jia, Zhang Yang, Wang Zhiyi

2024, 9(4):  36-39.  DOI: ［DOI］10. 3969 / j. issn. 2096-2266. 2024. 04. 007

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〔Abstract〕 Objective: To conduct follow-up and clinical data analysis of patients undergoing endovascular abdominal aortic repair

（EVAR） for abdominal aortic aneurysms, aiming to enhance understanding of postoperative complications and guide clinical practices. Methods: A retrospective analysis of clinical data from 96 EVAR patients treated at the First Affiliated Hospital of Dali University from January 2012 to December 2021 was conducted. Patients were divided into experimental and control groups based on whether internal iliac artery spring coil embolization was performed. The occurrence of pelvic ischemia-related complications

（gluteal muscle atrophy, claudication, sexual dysfunction, etc.） was observed and compared between the two groups. Results: In the experimental group, 6 patients （18.2%） experienced claudication, and 4 patients （12.1%） developed gluteal muscle atrophy. In the control group, 1 patient （1.6%） in each category experienced claudication and gluteal muscle atrophy. The total incidence of pelvic ischemia-related complications in the experimental group was significantly higher than that in the control group, with statistical significance （P<0.05）. No patients in the experimental group experienced type Ⅱ endoleak, while 2 patients（3.2%） in the control group developed type Ⅱ endoleak. Conclusion: Internal iliac artery spring coil embolization can to some extent prevent the occurrence of type Ⅱ endoleak after EVAR. However, the potential pelvic ischemia-related complications need to be carefully balanced. During EVAR, efforts should be made to ensure the patency of the internal iliac artery and pelvic circulation to minimize the occurrence of postoperative complications.




Diagnosis and Treatment Analysis of Single Center Bilateral Adrenal Gland Masses in Dali Area

Li Zufang, Sun Shuguang, Zhao Xueyan, Kuang Shiquan, Li Lihua, Yang Li

2024, 9(4):  40-45.  DOI: ［DOI］10. 3969 / j. issn. 2096-2266. 2024. 04. 008

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〔Abstract〕 Objective: To explore the etiological types, diagnosis and treatment for patients with bilateral adrenal gland masses.

Methods: A retrospective analysis of clinical data from 26 cases of bilateral adrenal gland masses treated at the First Affiliated Hospital of Dali University from January 2017 to October 2023 was conducted. Results: The distribution of etiological types of bilateral adrenal gland masses were primarily tuberculosis, non-functional adenomas, and primary aldosteronism （PA）. For adrenal gland masses with abnormal hormone secretion, differentiation of the dominant functional side was necessary. Conservative medical treatment was preferred for stable tuberculosis lesions, non-functional adenomas, and functional adenomas where the dominant side cannot be determined. Surgical intervention was considered for larger, unstable tuberculosis lesions, confirmed functional dominance in PA, or pheochromocytoma. Bilateral metastatic tumors could be treated with a combination of radiotherapy, chemotherapy, and immunotherapy. Conclusion: The choice of treatment strategy for bilateral adrenal gland masses depends on the etiology. In addition to addressing the adrenal lesions, tailored management of associated metabolic abnormalities is essential. A multidisciplinary approach can provide comprehensive and individualized treatment plans, ensuring optimal therapeutic outcomes for patients.




Clinical Study of Dexamethasone Implant Combined with Conbercept in the Treatment of Macular Edema with Branch Retinal Vein Occlusion

Liu Teng , Duan Zhiguang

2024, 9(4):  46-51.  DOI: ［DOI］10. 3969 / j. issn. 2096-2266. 2024. 04. 009

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〔Abstract〕 Objective: To evaluate the clinical efficacy of dexamethasone implant（Ozurdex） combined with conbercept in the treatment of macular edema with branch retinal vein occlusion（BRVO-ME）. Methods: A total of 168 patients with BRVO-ME were divided into conbercept group, Ozurdex group, and combination group according to the treatment regimen. The best corrected visual acuity（BCVA）, macular volume （MV）, central foveal thickness （CFT）, central retinal thickness （CRT）, intraocular pressure（IOP）, and incidence of complications were analyzed and compared among the three groups after treatment. Results

: The BCVA, CFT,  MV, and CRT of patients in all three groups were significantly improved at each point after treatment compared to before treatment, with statistically significant differences （P<0.05）. The IOP of patients in all three groups remained relatively stable after treatment, but patients in the Ozurdex group and combination group showed increased IOP after treatment compared to before treatment. Conclusion: Ozurdex combined with conbercept in the treatment of BRVO-ME can provide patients with visual and anatomical benefits with relatively fewer injections, and its therapeutic effect is significantly better than that of monotherapy.




Pathogenic Bacterial Distribution and Antimicrobial Resistance Analysis in the Intensive Care Unit Patients of a Hospital in Yunnan

Shen Botong, Wei Yifei, Yang Qiming, Wang Yuxin, Zhang Yuheng, Ma Lifan, Wu Youcong

2024, 9(4):  52-58.  DOI: ［DOI］10. 3969 / j. issn. 2096-2266. 2024. 04. 010

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〔Abstract〕 Objective: To explore the distribution of pathogenic bacterial and assess the antimicrobial resistance of ESKAPE pathogens （Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumanii, Pseudomonas aeruginosa, and Enterobacter spp.） and Escherichia coli in the intensive care unit （ICU） of a Yunnan hospital. Methods: Clinical specimens from ICU patients in a hospital in Yunnan from June 2020 to June 2021 were collected and isolated for culture. The cultures were identified and drug susceptibility tested by a fully automated microbial analysis system. WHONET 5.6 and SPSS 25.0 software were used for statistical analysis of data. Results: Among 590 specimens from 313 ICU patients, 675 pathogenic strains were isolated. Gram-negative bacteria constituted 480 strains（71.1%）, with Klebsiella pneumoniae, Acinetobacter baumannii, and Escherichia coli as predominant species. Gram-positive bacteria accounted for 140 strains（20.7%）, mainly Staphylococcus aureus. Fungi comprised 55strains（8.2%）, primarily Candida albicans. ESKAPE pathogens constituted 57.6% of isolates. Conclusion: The top five pathogenic microorganisms in this ICU were Klebsiella pneumoniae, Acinetobacter baumannii, Escherichia coli, Staphylococcus aureus, and Pseudomonas aeruginosa, all exhibiting varying degrees of antimicrobial resistance. 




Clinical Efficacy of Ultrasound-Guided Hydrodissection Combined with Acupotomy Release in the Treatment of Carpal Tunnel Syndrome#br#

Xu Jiashun, Wang Wenlei, Li Xiaodong, Yang Yanshu, Yang Zibin

2024, 9(4):  59-63.  DOI: ［DOI］ 10. 3969 / j. issn. 2096-2266. 2024. 04. 011

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〔Abstract〕 Objective: To analyze the clinical efficacy of ultrasound-guided nerve hydrodissection combined with acupotomy for
releasing the transverse carpal ligament in the treatment of carpal tunnel syndrome. Methods: A total of 45 patients （64 wrists）


diagnosed with carpal tunnel syndrome from June 2022 to December 2022 at Dali Bai Autonomous Prefecture People's Hospital were included in the study. According to the treatment plan, they were divided into the combined group and the hydrodissection-only group. The combined group underwent hydrodissection combined with acupotomy for releasing the transverse carpal ligament, while the hydrodissection-only group received hydrodissection with steroid solution. The anteroposterior diameter and cross-sectional area of the median nerve were measured before and 12 weeks after treatment. Pain and wrist joint function were assessed using the Visual Analogue Scale （VAS） and Boston Carpal Tunnel Questionnaire （BCTQ） before treatment, 4 weeks, and 12 weeks after treatment. Results: After 12 weeks of treatment, the anteroposterior diameter and cross-sectional area of the median nerve in both groups were significantly improved compared to before treatment （P<0.05）. The improvements in the anteroposterior diameter and cross-sectional area were more significant in the combined group than in the hydrodissection-only group （P<0.05）. Both groups showed significant improvements in VAS and BCTQ scores after 12 weeks of treatment compared to before treatment （P<0.01）, and the combined group had significantly lower scores than the hydrodissection-only group at 12 weeks （P<0.05）. Conclusion: Ultrasound-guided nerve hydrodissection combined with acupotomy for releasing the transverse carpal ligament is more beneficial for continuous improvement of symptoms and function in patients with carpal tunnel syndrome than hydrodissection alone, and it is worth promoting clinically.

Value of Left Ventricular Systolic Function in Normal Individuals Using Tissue Mitral Annular Displacement Technique

Li Kui, Cao Xin, Su Jingya, Chang Jicheng, Liu Yan

2024, 9(4):  64-68.  DOI: ［DOI］10. 3969 / j. issn. 2096-2266. 2024. 04. 012

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〔Abstract〕 Objective: To investigate the feasibility of tissue mitral annular displacement（TMAD） technique in evaluating left

ventricular systolic function. Methods: A total of 100 healthy volunteers were selected for the study. Left ventricular ejection fraction（LVEF） was measured by simplified biplane Simpson method. TMAD was applied to measure and calculate the mean value of the maximum displacement at 4 sites of the mitral ring （TMAD-mean）, the mean value of the maximum displacement in the midpoint of the insertion point around the mitral ring （TMAD-midpt） and its percentage in the diastolic left ventricular diameter（TMAD-midpt%）. The correlation between TMAD parameters and LVEF was analyzed. Results: TMAD-mean, TMAD-midpt, and TMAD-midpt% were significantly positively correlated with LVEF （P<0.001）, with TMAD-midpt% showing the strongest correlation（r=0.813）. Conclusion:TMAD technique is a novel method for evaluating left ventricular systolic function.




Image Assessment and Application of Homogeneous Bedside Radiography in Newborns with Pulmonary Diseases

Zhao Jiachun, Lin Yongfen, Yang Liping, Zhang Rendong, Wen Huachang

2024, 9(4):  69-73.  DOI: ［DOI］ 10. 3969 / j. issn. 2096-2266. 2024. 04. 013

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〔Abstract〕 Objective: To evaluate the application effectiveness of homogeneous bedside radiography in the diagnosis of pulmonary diseases in newborns and its role in dynamic time-window treatment in clinical practice. Methods: A retrospective analysis was conducted on 295 sets of bedside digital radiography （DR） chest images from 132 ill newborns in the neonatal intensive care unit of Chuxiong Yi Autonomous Prefecture People's Hospital from January 2020 to February 2022. The images were divided into two groups based on the shooting conditions, and the lesion descriptions and diagnostic analyses of the two groups were compared. Results: Homogeneous, high-quality chest images showed minimal differences in image quality. They facilitated relatively objective descriptions or clear diagnoses of pulmonary lesions, aiding in evaluating changes in the same lesion location between repeated examinations. Compared to chest images taken based on individual habits or experience, homogeneous bedside images showed better image consistency, contrast, and improved visibility of bronchial pulmonary markings in the same location and level. The ability to dynamically assess changes and reduce missed diagnoses between repeated examinations significantly improved, with statistical significance （P<0.01）. Conclusion: Homogeneous bedside DR chest imaging is an effective diagnostic method for dynamic timewindow imaging and differential diagnosis of pulmonary diseases in newborns. It contributes to evaluating treatment outcomes, guiding clinical interventions, and improving diagnostic accuracy.



Visual Analysis of LncRNA Research in Non-Small Cell Lung Cancer Based on Web of Science

Qiu Youzheng, Wang Jing

2024, 9(4):  74-81.  DOI: ［DOI］ 10. 3969 / j. issn. 2096-2266. 2024. 04. 014

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〔Abstract〕 Objective: To explore the literature on long noncoding RNA（ lncRNA） related to non-small cell lung cancer（NSCLC） in the field of oncology over the past decade. The analyze research hot spots and development trends in order to provide a reference for further research on lncRNA in the field of lung cancer. Methods: Literature related to NSCLC and lncRNA from 2013 to 2022 was retrieved from the Web of Science core database. Bibliometric analysis and visualization were conducted using the Bibliometrix packages in the R programming language, and CiteSpace, VOSviewer software. Results: A total of 473 articles were included in the analysis. The publication volume on NSCLC-related lncRNA showed an overall increasing trend, with China and the United States being the top contributors. Research focused mainly on aspects such as metastasis and proliferation in lung cancer. Frontline research concentrated on lncRNA as a biomarker and therapeutic target for tumors, as well as studies on relevant regulatory mechanisms. Conclusion: NSCLC-related lncRNA remains a recent research hotspot. Although China has a high publication volume in this field, the quality and impact of the literature still need improvement.



The Current Situation and Influencing Factors of the Quality of Life of Drug Addicts in Compulsory Isolation Detoxification during the Recovery Period#br#

Wu Yuanyuan, Zhao Na, Zhang Xiong, Hu Guifang, Wu Kunli

2024, 9(4):  82-87.  DOI: ［DOI］ 10. 3969 / j. issn. 2096-2266. 2024. 04. 015

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〔Abstract〕 Objective: To understand the quality of life of drug addicts in compulsory isolation detoxification （hereinafter referred to as "compulsory detoxification personnel"） during the recovery period and explore its influencing factors. Methods: "The drug addict's life quality measurement scale （QOL-DA V2.0）" was used to conduct a questionnaire survey of compulsory detoxification personnel during the recovery period in a hospital of Kunming Public Security Compulsory Drug Rehabilitation Center. Results: A total of 333 valid questionnaires were collected. The scores of physical function, psychological function, symptom/toxic and side effects and social function of the 333 participants were （32.63±7.22）, （35.13±7.80）, （47.11±8.90） and （38.25±6.68）, respectively. The total quality of life score was （153.11±25.88）. The multi-factor analysis results showed that gender, age, marital status, chronic diseases, drug relapse, whether drug addiction can be quit, and monthly family income had an impact on different dimensions. Conclusion: The quality of life of compulsory detoxification personnel during the recovery period in a hospital of Kunming Public Security Compulsory Drug Rehabilitation Center needs to be further improved. Affected by many factors, the public security compulsory detoxification center hospital should pay more attention to the compulsory detoxification personnel with chronic diseases and drug relapse, improve the health service capacity of compulsory detoxification medical treatment, and strengthen resource integration to improve the quality of life of compulsory detoxification personnel during the recovery period.



Visual Analysis of Research of AIDS in Men Who Have Sex with Men Based on Web of Science

Ma Qiu, Duan Jing, Yang Rui, Chen Lirong, Lu Yumiao, He Qilian

2024, 9(4):  88-94.  DOI: ［DOI］ 10. 3969 / j. issn. 2096-2266. 2024. 04. 016

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〔Abstract〕 Objective: To analyze the current status, hotspots and research trends of men who have sex with men （MSM）-related AIDS using bibliometric methods and to provide references for AIDS prevention and treatment research. Methods: The literature related to MSM-related AIDS in the Web of Science core collection database was collected by computer search, and CiteSpace software was used to analyze author collaboration and institutional distribution, and to map the keyword co-occurrence and clustering knowledge maps. Results: A total of 5 221 MSM-related AIDS research papers were included, and the number of published papers showed an overall upward trend. The country with the highest number of articles was the United States, and the institution with the highest number of articles was the University of California at San Francisco. The journal with the largest number of publications was AIDS and Behavior, with Mayer as the core author. The high frequency keywords included in the study were HIV/AIDS, gay men, infection, risk behavior, prevention. Conclusion: The research on MSM-related AIDS is in a positive state, with rich research topics, concentrated hotspots and high degree of cooperation among authors. In the future, it is necessary to continue to explore active and effective intervention measures, early and comprehensive identification of MSM at risk of infection, rapid initiation of antiretroviral therapy, attention to the mental health of MSM population, and construction of a good social support and care system.




Contents of Nitrogen, Phosphorus, Arsenic and Metals in Soils around Erhai Lake and Their Potential Ecological Risk Assessment#br#

Lei Xiaoyi, Chen Kaijie, He Tian, Deng Zhixin, Lu Xuan, Sui Shiyan

2024, 9(4):  95-100.  DOI: ［DOI］ 10. 3969 / j. issn. 2096-2266. 2024. 04. 017

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〔Abstract〕 Objective: To understand the content of related elements in the soil around Erhai Lake, and to provide a scientific basis for soil environmental quality evaluation, potential risk assessment, protection and comprehensive management of Erhai Lake. Methods: Soil samples from different sites around Erhai Lake were selected to determine the contents of 8 elements, such as

manganese （Mn）, zinc （Zn）, calcium （Ca）, copper （Cu）, cobalt （Co）, nitrogen （N）, phosphorus （P） and arsenic （As）. The soil quality and potential ecological risk were analyzed and evaluated by geoaccumulation index and potential ecological risk index of heavy metals. Results: The average mass content of Zn, Cu and As did not exceed the risk screening value. The indexes of geoaccumulation of Mn, Zn, Cu, Co and As were less than 0；the grades of N and P in soil were the fifth and fourth grades respectively. Polymetallic potential ecological risk index was 12.85. Conclusion: The accumulation degree of metals in the soil of the study area is low and less affected by human activities, the potential ecological risk of heavy metals is slight, and the N and P elements in the soil show the imbalance of nutrient regions.