The price of Sichuan refined oil is influenced by various factors, macroscopically, it is influenced by the international and domestic oil price; regionally, by the natural conditions and the refined oil market in Sichuan. What’s more, these influencing factors’ interplay is complex. In order to have a systematic study on the influencing factors of the price of Sichuan refined oil to provide policy decision basis to stabilize the price of Sichuan refined oil and set up good market order, the article uses the principles and methods of systematic engineering to analyze the factors and the chain that influence the price of Sichuan refined oil and set up ISM (Interpretive Structural Mode). By the analysis of the model, the direct cause influencing the price of Sichuan refined oil has been found out, that is, domestic oil price and Sichuan oil market situation; the superficial cause has three factors: the demands, supplies and competition in Sichuan refined oil market; the secondary cause is Sichuan industrial structure and the increasing of energy consumption; the complicated cause is oil reserve system, imports exports, fuel tax and smuggling; the fundamental causes are international oil price, the natural transportation condition in Sichuan, the substitute energy, market management, and so on. Aimed at the influencing factors of different causes, the corresponding policy marking proposals is provided.