关键词: font-family:宋体, ">精神分裂症；肠道菌群；高通量测序；病期控制；家族史

Abstract:

 Objective： To investigate the relationship between intestinal flora structure and different stages of schizophrenia patients with or without family history. Methods： Hospitalized patients with schizophrenia from December 2017 to August 2018 in the psychiatry department of the Ｓecond Hospital of Dali Bai Autonomous Prefecture were chosen as the subjects， whose excrement were collected in attack period and control period， and their structures of intestinal flora in different disease periods were tested with high- throughput sequencing. Results： Phylum with the highest relative abundance among the samples was Firmicutes. Ascomycetes with the highest relative abundance was Fusobacteria. The dominant bacteria genera were Bacteroidetes， Faecalis， Escherichia coli - Shigella， Lactobacillus， etc. Diversity analysis showed that there were statistically significant differences among all groups （P<0.05）. Species-difference analysis suggested that the dominant species in the control stage of the patient was propionic bacilli of Actinomycetes， and the dominant species in the attack stage was CAG-56 genus of Pilospiraceae of Firmicutes. The dominant species in patients with family history was the family F082 of Bacteroidetes， and the dominant species in patients without family history was the family Succinvibrio of Proteobacteria. Conclusion： There are differences in the structure and diversity of intestinal flora between patients with schizophrenia during attack and control periods， and there may be a relationship between disease control and the structure of intestinal flora.

Key words: font-family:Times New Roman, ">schizophreniafont-family:Times New Roman, ">；font-family:Times New Roman, "> intestinal florafont-family:Times New Roman, ">；font-family:Times New Roman, "> high-throughput sequencingfont-family:Times New Roman, ">；font-family:Times New Roman, "> disease controlfont-family:Times New Roman, ">；font-family:Times New Roman, "> family history