Protective Effect of Periplaneta Americana Extract CII-3 against Arrhythmia in Rats

J4 ›› 2011, Vol. 10 ›› Issue (12): 6-9.

Protective Effect of Periplaneta Americana Extract CII-3 against Arrhythmia in Rats

Objective: To explore the protective effect and mechanism of CII-3 extracted from Periplaneta americana against
arrhythmia induced by aconitine in rats. Methods: Arrhythmia in rat was induced by aconitine with femoral vein injection, with different doses of CII-3 treatment, the incidence rates of ventricular premature beats（VP）, ventricular tachycardia（VT）, ventricular fibrillation （VF）and cardiac arrest （CA）were recorded, and the arrhythmia score, activity of CK and LDH were detected. Results:The amount of aconitine in inducing VP, VT, VF and CA was increased after CII-3 treatment, which showed decreased incidences of VT, VF, CA and the arrhythmia score, as well as the the activity of CK （P<0.05）. However, there was no influence of CII-3 on the activity of LDH. Conclusion: The data demonstrated that there was remarkable protective effect of CII-3 against arrhythmia induced by aconitine in rats.

1. Department of Anesthesiology, People's Hospital of Mangshi, Dehong, Yunnan 678400, China;
2. School of Pharmacy and Chemistry, Dali University, Dali, Yunnan 671000, China

Received:2011-06-08 Revised:2011-09-15 Online:2011-12-15 Published:2011-12-15

Abstract

Abstract:

Key words: Periplaneta americana, CII-3, arrhythmia, aconitine

CLC Number:

R 285.5

PENG Li, LU Li, ZHANG Xu-Qiang, GAN Ping, HE Xu, CHEN Jun-Ya, PENG Fang. Protective Effect of Periplaneta Americana Extract CII-3 against Arrhythmia in Rats[J]. J4, 2011, 10(12): 6-9.

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