A Study on Therapeutic Mechanism of Ephedrae Herba-Cinnamomi Ramulus Herbal Pair in
Treating Hydropsy

Abstract

Abstract:

〔Abstract〕Objective：To predict the mechanism of ephedrae herba-cinnamomi ramulus herbal pair in treating hydropsy by using
network pharmacology technique. Methods: TDT and TCMSP databases were used to screen the chemical composition of ephedrae
herba and cinnamomi ramulus; OMIM database screened the targets of hydropsy. A "compound-target-disease" complex network
diagram was constructed with Cytoscape software. In the "component-target-disease" network of ephedrae herba and cinnamomi
ramulus, the gene function and KEGG path of the selected targets were analyzed. Results: 10 protein targets effective in treating
hydropsy had been screened. It was found that their treating effect was achieved mainly through regulating VEGF signaling pathway
and vascular endothelial cell migration. PI3K-Akt signaling pathway, TNF signaling pathway, Ras signaling pathway and MAPK
signaling pathway also played significant roles. Conclusion: The mechanism of ephedrae herba and cinnamomi ramulus in the
treatment of hydropsy has been predicted by network pharmacology, which can provide the theoretical basis for its clinical application.

Key words: 〔Key words〕network pharmacology, ephedrae herba-cinnamomi ramulus herbal pair, hydropsy, mechanism

CLC Number:

R285

Hao Junjie, Li Yang. A Study on Therapeutic Mechanism of Ephedrae Herba-Cinnamomi Ramulus Herbal Pair in
Treating Hydropsy[J]. , 2018, 3(10): 7-12.

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