Abstract: 〔Abstract〕Objective: To improve the anti-Alzheimer′s disease activities of secoiridoid glycoside Secologanol. The aim of this study
is to modify the structure of Secologanol and synthesize its corresponding acylation products, so as to enhance the structural stability
and activity of its derivatives and lay a foundation for further structural modification. Methods: Secologanol was acylated with acetic
anhydride and benzoyl chloride respectively by controlling the equivalent of acylating agent and its reaction time. Results: The
acetylation and benzoylation products could be synthesized quickly and efficiently. Conclusion: New Secologanol acylation products 1,
3, 4 and 5 are synthesized. Besides, the reaction has good reproducibility with high yield and stable structure of acylation products,
which can be used for further structural modification and activity test.

Key words: 〔Key words〕seroiridoid glycoside, Secologanol, structural modification, acylation products